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480418 NF279 - CAS 202983-32-2 - Calbiochem

A suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC₅₀/KB ~ 1 µM in smooth muscle).

NF279 - CAS 202983-32-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 8,8ʹ-(Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino))bis-1,3,5-naphthalenetrisulfonic Acid, Na

Primary Target: P2X receptor
480418
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
202983-32-2C₄₉H₃₀N₆O₂₃S₆ · 6Na

Products

Catalogue NumberPackaging Qty/Pack
480418-5MGCN Plastic ampoule 5 mg
Description
OverviewA suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC50/KB ~ 1 µM in smooth muscle). Effectively discriminates between P2Y and P2X receptors with no effect on α1A adrenoceptors, adenosine A1 and A2B receptors, histamine H1, muscarinic M3 and neuronal nicotinic acetylcholine receptors. Displays a selectivity profile of P2X1 >P2X2 >P2X3 >P2X4 (IC50 = 19 nM, 770 nM, 1.62 µM and >300 µM, respectively) in Xenopus oocytes pre-incubated with ATP. In rat and human tissues, exhibits a potency profile of rat P2X1 > human P2X1 > > rat P2X2 > rat P2X3 ~ human P2X7 > > human P2X4. Not degraded by ecto-nucleotidases.
Catalogue Number480418
Brand Family Calbiochem®
Synonyms8,8ʹ-(Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino))bis-1,3,5-naphthalenetrisulfonic Acid, Na
References
ReferencesKlapperstück, M., et al. 2000. Eur. J. Pharmacol. 387, 245.
Rettinger, J., et al. 2000. Neuropharmacol. 39, 2044.
Lambrecht, G., et al. 1999. Prog. Brain Res. 120,107.
Damer, S., et al. 1998. Eur. J. Pharmacol. 350, R5.
Product Information
CAS number202983-32-2
ATP CompetitiveY
FormWhite solid
Hill FormulaC₄₉H₃₀N₆O₂₃S₆ · 6Na
Chemical formulaC₄₉H₃₀N₆O₂₃S₆ · 6Na
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetP2X receptor
Primary Target IC<sub>50</sub>~ 1 µM as antagonist of P2X receptor in smooth muscle; 19 nM, 770 nM, 1.62 µM and <300 µM, against P2X1, P2X2, P2X3, P2X4, respectively, in Xenopus oocytes pre-incubated with ATP
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
480418-5MGCN 04055977201352

Documentation

NF279 - CAS 202983-32-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

NF279 - CAS 202983-32-2 - Calbiochem Certificates of Analysis

TitleLot Number
480418

References

Reference overview
Klapperstück, M., et al. 2000. Eur. J. Pharmacol. 387, 245.
Rettinger, J., et al. 2000. Neuropharmacol. 39, 2044.
Lambrecht, G., et al. 1999. Prog. Brain Res. 120,107.
Damer, S., et al. 1998. Eur. J. Pharmacol. 350, R5.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-August-2008 RFH
Synonyms8,8ʹ-(Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino))bis-1,3,5-naphthalenetrisulfonic Acid, Na
DescriptionA suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC50/KB ~1 µM in smooth muscle). Effectively discriminates between P2Y and P2X receptors with no discernible effects on α1A adrenoceptors, adenosine A1 and A2B receptors, histamine H1, muscarinic M3 and neuronal nicotinic acetylcholine receptors. Displays a selectivity profile of P2X1 >P2X2 >P2X3 >P2X4 (IC50 = 19 nM, 770 nM, 1.62 µM and >300 µM, respectively) in Xenopus oocytes pre-incubated with ATP. In rat and human tissues, exhibits a potency profile of rat P2X1 > human P2X1 » rat P2X2 > rat P2X3 ~human P2X7 » human P2X4. Not degraded by ecto-nucleotidases.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number202983-32-2
Chemical formulaC₄₉H₃₀N₆O₂₃S₆ · 6Na
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (14 mg/ml) or H₂O (35 mg/ml)
Storage Protect from moisture
Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesKlapperstück, M., et al. 2000. Eur. J. Pharmacol. 387, 245.
Rettinger, J., et al. 2000. Neuropharmacol. 39, 2044.
Lambrecht, G., et al. 1999. Prog. Brain Res. 120,107.
Damer, S., et al. 1998. Eur. J. Pharmacol. 350, R5.