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480010 NDSB-256 - CAS 81239-45-4 - Calbiochem

A non-detergent sulfobetaine. Reported to prevent protein aggregation and facilitate the renaturation of chemically and thermally denatured proteins.

NDSB-256 - CAS 81239-45-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Dimethylbenzylammonium Propane Sulfonate

480010
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
81239-45-4C₁₂H₁₉NO₃S

Products

Catalogue NumberPackaging Qty/Pack
480010-25GMCN Plastic ampoule 25 gm
480010-5GMCN Plastic ampoule 5 gm
Description
OverviewA non-detergent sulfobetaine. Reported to prevent protein aggregation and facilitate the renaturation of chemically and thermally denatured proteins. Zwitterionic over a wide pH range. Easily removed by dialysis. At 1 M, NDSB-256 will restore 30% of the enzymatic activity of denatured egg white lysozyme; at 800 mM it will restore 16% of the enzymatic activity of denatured β-galactosidase.
Catalogue Number480010
Brand Family Calbiochem®
SynonymsDimethylbenzylammonium Propane Sulfonate
References
ReferencesGoldberg, M.E., et al. 1996. Folding & Design 1, 21.
Product Information
CAS number81239-45-4
FormWhite solid
Hill FormulaC₁₂H₁₉NO₃S
Chemical formulaC₁₂H₁₉NO₃S
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by TLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +15°C to +30°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store at room temperature (15-30°C). Stock solutions are stable for up to 3 months at room temperature.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
480010-25GMCN 07790788050610
480010-5GMCN 04055977201802

Documentation

NDSB-256 - CAS 81239-45-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

NDSB-256 - CAS 81239-45-4 - Calbiochem Certificates of Analysis

TitleLot Number
480010

References

Reference overview
Goldberg, M.E., et al. 1996. Folding & Design 1, 21.

Brochure

Title
Biological Detergents Brochure
Bulk Product Guide
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision02-April-2012 JSW
SynonymsDimethylbenzylammonium Propane Sulfonate
DescriptionA member of the class of nondetergent sulfobetaines. Unlike CHAPS and other zwittergents, NDSBs are nondenaturing even at 1 M concentrations. NDSBs have been used to improve the efficiency of solubilization of membrane proteins, to isolate nuclear proteins, to chromatographically purify halophilic proteins in low ionic strength buffers, and to crystallize proteins. They are zwitterionic over a wide pH range and do not absorb significantly in the near UV range. Reported to prevent protein aggregation and facilitate the renaturation of chemically and thermally denatured proteins. NDSBs can be easily removed by dialysis. At 1 M, NDSB-256 will restore 30% of the enzymatic activity of denatured egg white lysozyme; at 800 mM it will restore 16% of the enzymatic activity of denatured β-galactosidase.
FormWhite solid
CAS number81239-45-4
Chemical formulaC₁₂H₁₉NO₃S
Structure formulaStructure formula
Purity≥99% by TLC
SolubilityH₂O (200 mg/ml)
Storage +15°C to +30°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, store at room temperature (15-30°C). Stock solutions are stable for up to 3 months at room temperature.
Toxicity Irritant
ReferencesGoldberg, M.E., et al. 1996. Folding & Design 1, 21.