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FCMAB318PE Milli-Mark™ Anti-MAP2-PE Antibody, clone AP20

Milli-Mark Anti-MAP2-PE Antibody, clone AP20 is an antibody against MAP2 for use in FC.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neuronal & Glial Markers Gene Symbol: MAP2 UniProt Number: P11137
FCMAB318PE
100 tests  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HFCMPhycoerythrinMonoclonal Antibody
Description
Catalogue NumberFCMAB318PE
Trade Name
  • Milli-Mark
DescriptionMilli-Mark™ Anti-MAP2-PE Antibody, clone AP20
Alternate Names
  • Microtubule-associated protein 2
Background InformationMAP-2 (microtubule associated protein-2) is one of several high molecular weight proteins that play an important role in brain neuron microtubule assembly. In addition to its association with microtubules, MAP-2 associates with neurofilaments and actin filaments suggesting that it may guide interaction among microtubules, other cytoskeletal elements, and cytoplasmic organelles. MAP-2 is a stringent marker for neurons. In addition, MAP-2 displays intracellular specificity. In the central nervous system, MAP-2 is confined to neuronal cell bodies and dendrites. There are exceptions, however, where some axons stain positive for small amounts of MAP-2. MAP-2 is uniformly distributed throughout the cell when first expressed in cultured neurons but becomes selectively localized as dendritic development proceeds. (Caceres, 1986; Dotti, 1987).
Product Information
FormatPhycoerythrin
Control
  • U251 cells
PresentationPurified mouse monoclonal IgG1 conjugated to PE in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Quality LevelMQ100
Applications
ApplicationMilli-Mark Anti-MAP2-PE Antibody, clone AP20 is an antibody against MAP2 for use in FC.
Key Applications
  • Flow Cytometry
Biological Information
ImmunogenRecombinant Bovine brain microtubule protein.
CloneAP20
HostMouse
SpecificityAntibody recognizes MAP-2.
IsotypeIgG1
Species Reactivity
  • Human
Species Reactivity NoteTested and passed on Human. Predicted to react on Bovine based on immunogen designed.
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isforms have been described.
Gene Symbol
  • MAP2
Purification MethodProtein A Purfied
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P11137 # The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

SIZE: 1827 amino acids; 199539 Da

PTM: MAP2A/c is phosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.

SIMILARITY: SwissProt: P11137 ## Contains 3 Tau/MAP repeats.
Molecular Weight 199.5 kDa Calculated
Product Usage Statements
Quality AssuranceEvaluated by flow cytometry using U251 cells
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain refrigerated at 2-8°C protected from light for up to 6 months from date of receipt.
Packaging Information
Material Size100 tests
Global Trade Item Number
Catalogue Number GTIN
FCMAB318PE 04053252630293