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444293 MMP-9 Inhibitor II - CAS 502887-71-0 - Calbiochem

The MMP-9 Inhibitor II controls the biological activity of MMP-9. This small molecule/inhibitor is primarily used for Biochemicals applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: MMP-9 PEX Inhibitor

444293
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
502887-71-0C₁₆H₁₇F₂N₃O₃S

Products

Catalogue NumberPackaging Qty/Pack
444293-10MGCN Glass bottle 10 mg
Description
OverviewThis compound is a cell-permeable, selective, and reversible thiopyrimidone MMP-9 allosteric inhibitor that binds specifically to the non-catalytic site of MMP-9 at the PEX domain with a Kd = 2.1 µM and thereby disrupts MMP-9 homodimerization and its cross-talk with CD44 and the EGFR-MAPK signaling pathway. It does not bind to the PEX domain of MMP-2 or MT1-MMP and it is shown to decrease MMP-9 mediated cell migration in COS-1 cells at 100 µM. Also, it inhibits cell migration and invasion of HT-1080 and MDA-MB-435 human cancer cells in a dose-dependent manner from 0.1 to 100 µM, without altering MMP-9 expression or proteolytic activity in HT-1080 cells. In addition, it attenuates both primary tumor growth and metastasis in vivo in a mouse model without obvious toxicity (20 mg/kg, 6 days/week, i.v. and i.t.).
Catalogue Number444293
Brand Family Calbiochem®
SynonymsMMP-9 PEX Inhibitor
References
ReferencesDufour, A., et al. 2011. Cancer Res. 71, 4977.
Product Information
CAS number502887-71-0
FormYellow-white solid
Hill FormulaC₁₆H₁₇F₂N₃O₃S
Chemical formulaC₁₆H₁₇F₂N₃O₃S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
444293-10MGCN 04055977186093

Documentation

MMP-9 Inhibitor II - CAS 502887-71-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

MMP-9 Inhibitor II - CAS 502887-71-0 - Calbiochem Certificates of Analysis

TitleLot Number
444293

References

Reference overview
Dufour, A., et al. 2011. Cancer Res. 71, 4977.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-April-2012 JSW
SynonymsMMP-9 PEX Inhibitor
DescriptionThis compound is a cell-permeable, selective, and reversible thiopyrimidone MMP-9 allosteric inhibitor that binds specifically to the non-catalytic site of MMP-9 at the PEX domain with a Kd = 2.1 µM and thereby disrupts MMP-9 homodimerization and its cross-talk with CD44 and the EGFR-MAPK signaling pathway. It does not bind to the PEX domain of MMP-2 or MT1-MMP and it is shown to decrease MMP-9 mediated cell migration in COS-1 cells at 100 µM. Also, it inhibits cell migration and invasion of HT-1080 and MDA-MB-435 human cancer cells in a dose-dependent manner from 0.1 to 100 µM, without altering MMP-9 expression or proteolytic activity in HT-1080 cells. In addition, it attenuates both primary tumor growth and metastasis in vivo in a mouse model without obvious toxicity (20 mg/kg, 6 days/week, i.v. and i.t.).
FormYellow-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number502887-71-0
Chemical formulaC₁₆H₁₇F₂N₃O₃S
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml; light yellow solution)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesDufour, A., et al. 2011. Cancer Res. 71, 4977.