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444288 MMP-2 Inhibitor III - CAS 704888-90-4 - Calbiochem

The MMP-2 Inhibitor III, also referenced under CAS 704888-90-4, controls the biological activity of MMP-2. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (2-((Isopropoxy)-(1,1ʹ-biphenyl-4-ylsulfonyl)-amino))-N-hydroxyacetamide

Primary Target: MMP-2
444288
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
704888-90-4C₁₇H₂₀N₂O₅S

Products

Catalogue NumberPackaging Qty/Pack
444288-5MGCN Plastic ampoule 5 mg
Description
OverviewA cell-permeable biphenylsulfonamido-hydroxamate compound that acts a potent and Zn2+-binding site-targeting inhibitor of MMP-2 (IC50 = 12 nM). It exhibits good selectivity over MMP-9 and MMP-3 (IC50 = 0.2 and 4.5 µM, respectively) and shows practically no effect towards MMP-1 and MMP-7 (IC50 > 50 µM). Shown to effectively suppress the invasiveness of HT1080 sarcoma cells grown on matrigel.
Catalogue Number444288
Brand Family Calbiochem®
Synonyms(2-((Isopropoxy)-(1,1ʹ-biphenyl-4-ylsulfonyl)-amino))-N-hydroxyacetamide
References
ReferencesTuccinardi, T., et al. 2006. Bioorg. Med. Chem. 14, 4260.
Rossello, A., et al. 2004. Bioorg. Med. Chem. 12, 2441.
Product Information
CAS number704888-90-4
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₇H₂₀N₂O₅S
Chemical formulaC₁₇H₂₀N₂O₅S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMMP-2
Primary Target IC<sub>50</sub>12 nM against MMP-2
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
444288-5MGCN 04055977186055

Documentation

MMP-2 Inhibitor III - CAS 704888-90-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

MMP-2 Inhibitor III - CAS 704888-90-4 - Calbiochem Certificates of Analysis

TitleLot Number
444288

References

Reference overview
Tuccinardi, T., et al. 2006. Bioorg. Med. Chem. 14, 4260.
Rossello, A., et al. 2004. Bioorg. Med. Chem. 12, 2441.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
Synonyms(2-((Isopropoxy)-(1,1ʹ-biphenyl-4-ylsulfonyl)-amino))-N-hydroxyacetamide
DescriptionA cell-permeable biphenylsulfonamido-hydroxamate compound that acts a potent and Zn2+-binding site-targeting inhibitor of MMP-2 (IC50 = 12 nM). It exhibits good selectivity over MMP-9 and MMP-3 (IC50 = 0.2 and 4.5 µM, respectively) and shows practically no effect towards MMP-1 and MMP-7 (IC50 > 50 µM). Shown to effectively suppress the invasiveness of HT1080 sarcoma cells grown on matrigel.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number704888-90-4
Chemical formulaC₁₇H₂₀N₂O₅S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (200 mg/ml) or Methanol (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesTuccinardi, T., et al. 2006. Bioorg. Med. Chem. 14, 4260.
Rossello, A., et al. 2004. Bioorg. Med. Chem. 12, 2441.