475848 Sigma-AldrichMIF Antagonist V, p425 - CAS 259444 - Calbiochem
The MIF Antagonist V, p425, also referenced under CAS 2610-05-1, controls the biological activity of MIF. This small molecule/inhibitor is primarily used for Cell Structure applications.
More>> The MIF Antagonist V, p425, also referenced under CAS 2610-05-1, controls the biological activity of MIF. This small molecule/inhibitor is primarily used for Cell Structure applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Sodium 6,6ʹ-(1E,1ʹE)-(3,3ʹ-dimethoxybiphenyl-4,4ʹ-diyl)bis(diazene-2,1-diyl)bis(4-amino-5-hydroxynaphthalene-1,3-disulfonate)
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 2610-05-1 | C₃₄H₂₄N₆Na₄O₁₆S₄ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 475848-2GMCN | Glass bottle | 2 gm |
| Description | |
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| Overview | A symmetrical bis-(amino, hydroxynaphthalenedisulfonate) compound that antagonizes macrophage migration inhibitory factor against receptor binding (IC50 = 810 nM against hMIF and CD74 interaction) and is more potent than ISO-1 (Cat. No. 475837) in suppressing MIF-induced cytokines and MMP-3 productions in human fibroblasts cultures (IC50 = ≤0.7 µM vs >5 µM). Unlike MIF Antagonists I-IV, p425 targets an area at the interface of two MIF trimers, distal to the active site. |
| Catalogue Number | 475848 |
| Brand Family | Calbiochem® |
| Synonyms | Sodium 6,6ʹ-(1E,1ʹE)-(3,3ʹ-dimethoxybiphenyl-4,4ʹ-diyl)bis(diazene-2,1-diyl)bis(4-amino-5-hydroxynaphthalene-1,3-disulfonate) |
| References | |
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| References | Bai, F., et al. 2012. J. Biol. Chem. 287, 30653. |
| Product Information | |
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| CAS number | 2610-05-1 |
| Form | Blue solid |
| Hill Formula | C₃₄H₂₄N₆Na₄O₁₆S₄ |
| Hygroscopic | Hygroscopic |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | MIF |
| Purity | ≥95% by HPLC |
| Physicochemical Information |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 475848-2GMCN | 04055977185034 |
Documentation
MIF Antagonist V, p425 - CAS 259444 - Calbiochem SDS
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MIF Antagonist V, p425 - CAS 259444 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 475848 |
References
| Reference overview |
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| Bai, F., et al. 2012. J. Biol. Chem. 287, 30653. |
| Data Sheet | ||||||||||||||||||||||||||||
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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