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506291 Lactimidomycin - CAS 134869-15-1 - Calbiochem

This product can no longer be ordered through emdmillipore.com. Please refer to (Cat. No. 506291) on sigmaaldrich.com.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: LTM

Primary Target: Ribosome
506291
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
134869-15-1C₂₆H₃₅NO₆

Products

Catalogue NumberPackaging Qty/Pack
5.06291.0001.1753 Glass bottle 0.2 mg
Description
OverviewA glutarimide based 12-membered macrolide antibiotic with antifungal properties. Acts as a potent inhibitor of cell migration, cell proliferation, and protein synthesis (IC50 = 37.82 nM), but does not affect RNA synthesis even at high concentrations (IC50 > 10 µM). Acts as a potent inhibitor of translation and appears to block the first translocation step without affecting tRNA binding or peptide bond formation. It exhibits about 10-fold greater potency than cycloheximide (Cat. No. 239763 and 239764). Binds to the same site on the 60S ribosomal subunit with high affinity (Kd = 500 nM vs 15 µM for cycloheximide). Shown to extend the survival of mice bearing P388 lymphoma by blocking cell growth, however, it does not significantly affect non-tumorigenic MCF10A breast cell lines. Also shown to retard the growth of MDA MB231 cells in nude mice (~0.6 /mg/kg).
Catalogue Number506291
Brand Family Calbiochem®
SynonymsLTM
References
ReferencesSchneider-Poetsch, T., et al. 2010. Nat. Chem. Biol. 6, 209.
Micoine, K., et al. 2010. J. Am. Chem. Soc. 132, 14064.
Ju, J., et al. 2009. J. Am. Chem. Soc. 131, 1370.
Sugawara, K., et al. 1992. J. Antibiot. 45, 1433.
Product Information
CAS number134869-15-1
FormWhite powder
Hill FormulaC₂₆H₃₅NO₆
Chemical formulaC₂₆H₃₅NO₆
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetRibosome
Primary Target IC<sub>50</sub>37.8 nM, Kd
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.06291.0001.1753 04055977243215

Documentation

Lactimidomycin - CAS 134869-15-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Schneider-Poetsch, T., et al. 2010. Nat. Chem. Biol. 6, 209.
Micoine, K., et al. 2010. J. Am. Chem. Soc. 132, 14064.
Ju, J., et al. 2009. J. Am. Chem. Soc. 131, 1370.
Sugawara, K., et al. 1992. J. Antibiot. 45, 1433.

Brochure

Title
New Products Flyer- Feb 2014 - Vol 1
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-September-2013 JSW
SynonymsLTM
DescriptionA glutarimide based 12-membered macrolide antibiotic with antifungal properties. Acts as a potent inhibitor of cell migration, cell proliferation, and protein synthesis (IC50 = 37.82 nM), but does not affect RNA synthesis even at high concentrations (IC50 > 10 µM). Acts as a potent inhibitor of translation and appears to block the first translocation step without affecting tRNA binding or peptide bond formation. It exhibits about 10-fold greater potency than cycloheximide (Cat. No. 239763 and 239764). Binds to the same site on the 60S ribosomal subunit with high affinity (Kd = 500 nM vs 15 µM for cycloheximide). Shown to extend the survival of mice bearing P388 lymphoma by blocking cell growth, however, it does not significantly affect non-tumorigenic MCF10A breast cell lines. Also shown to retard the growth of MDA MB231 cells in nude mice (~0.6 /mg/kg).
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
CAS number134869-15-1
Chemical formulaC₂₆H₃₅NO₆
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSchneider-Poetsch, T., et al. 2010. Nat. Chem. Biol. 6, 209.
Micoine, K., et al. 2010. J. Am. Chem. Soc. 132, 14064.
Ju, J., et al. 2009. J. Am. Chem. Soc. 131, 1370.
Sugawara, K., et al. 1992. J. Antibiot. 45, 1433.