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524644 L-α-Phosphatidyl-D-myo-inositol-4,5-bisphosphate, Triammonium Salt, Porcine Brain - CAS 383907-42-4 - Calbiochem

A component of membrane-bound receptors in association with phospholipase C (PLC).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PIP₂

524644
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Overview

Key Spec Table

CAS #Empirical Formula
383907-42-4C₄₇H₈₂O₁₉P₃ · 3NH₄

Products

Catalogue NumberPackaging Qty/Pack
524644-100UGCN Plastic ampoule 100 μg
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524644-1MGCN Plastic ampoule 1 mg
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Description
OverviewA component of membrane-bound receptors in association with phospholipase C (PLC). Potently stimulates brain phospholipase D (PLD) activity in vitro. Has been shown to activate protein kinase C (PKC) in the presence of phosphatidylserine and Ca2+. Antagonist of ATP-sensitive potassium (KATP) channels when applied to inside-out membrane patches.
Catalogue Number524644
Brand Family Calbiochem®
SynonymsPIP₂
References
ReferencesBaukrowitz, T., et al. 1998. Science 282, 1141.
Shyng, S.-L., and Nichols, C.G. 1998. Science 282, 1138.
Mazzotti, G., et al. 1995. J. Histochem. Cytochem. 43, 181.
Liscovitch, M., et al. 1994. J. Biol. Chem. 269, 21403.
Chauhan, A., et al. 1991. Biochem. Biophys. Res. Commun. 175, 852.
Williamson, J.R. 1986. Hypertension 8, 140.
Berridge, M.J., and Irvine, R.F. 1984. Nature 312, 315.
Product Information
CAS number383907-42-4
ATP CompetitiveN
FormWhite to off-white solid
Hill FormulaC₄₇H₈₂O₁₉P₃ · 3NH₄
Chemical formulaC₄₇H₈₂O₁₉P₃ · 3NH₄
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetBrain phospholipase D (PLD)
Purity≥98% by TLC
Physicochemical Information
Cell permeableN
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Irritant
Storage ≤ -70°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution in H₂O, store in the refrigerator (4°C). Do not freeze aqueous solutions. Following reconstitution in chloroform, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 2 days at 4°C. Chloroform stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
524644-100UGCN 04055977197624
524644-1MGCN 04055977197617