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422175 L-165,041 - CAS 79558-09-1 - Calbiochem

A cell-permeable phenoxyacetic acid derivative that acts as a potent and selective peroxisome proliferator activator receptor δ (PPARδ) agonist (Ki = 6 nM for hPPARδ and 730 nM for hPPARγ).

L-165,041 - CAS 79558-09-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Compound P, L165041, 4-[3-(2-Propyl-3-hydroxy-4-acetyl)phenoxy]propyloxyphenoxy-acetic acid, PPAR Agonist VIII, PPARα Agonist III, PPARγ Agonist VII

Primary Target: Peroxisome proliferator activator receptor δ (PPAR@delta;)
422175
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
79558-09-1C₂₂H₂₆O₇

Products

Catalogue NumberPackaging Qty/Pack
422175-5MGCN Plastic ampoule 5 mg
Description
OverviewA cell-permeable phenoxyacetic acid derivative that acts as a potent and selective peroxisome proliferator activator receptor δ (PPARδ) agonist (Ki = 6 nM for hPPARδ and 730 nM for hPPARγ). Potently induces adipocyte differentiation in NIH-PPARδ cells at 500 nM and raises total cholesterol in insulin resistant db/db mice without altering glucose or triglycerides levels. Increases UCP3 (uncoupling protein 3) gene expression in L6 myotubes. Inhibits cytokine-induced expression of VCAM-1 (vascular cell adhesion molecule-1) and the secretion of MCP-1 (monocyte chemotactic protein-1) in EAhy926 cells.
Catalogue Number422175
Brand Family Calbiochem®
SynonymsCompound P, L165041, 4-[3-(2-Propyl-3-hydroxy-4-acetyl)phenoxy]propyloxyphenoxy-acetic acid, PPAR Agonist VIII, PPARα Agonist III, PPARγ Agonist VII
References
ReferencesRival, Y., et al. 2002. Eur. J. Pharmacol. 435, 143.
Castrillo, A., et al. 2001. J. Biol. Chem. 276, 34082.
Hansen, J.B., et al. 2001. J. Biol. Chem. 276, 3175.
Son, C., et al. 2001. Endocrinology 142, 4189.
Wilkie, N., et al. 2001. J. Neurochem. 78, 1135.
Leibowitz, M.D., et al. 2000. FEBS Lett. 473, 333.
Berger, J., et al. 1999. J. Biol. Chem. 274, 6718.
Lim, H., et al. 1999. Genes Dev. 13, 1561.
Product Information
CAS number79558-09-1
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₂H₂₆O₇
Chemical formulaC₂₂H₂₆O₇
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPeroxisome proliferator activator receptor δ (PPAR@delta;)
Primary Target K<sub>i</sub>6 nM for hPPARδ and 730 nM for hPPARγ
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
422175-5MGCN 04055977187144

Documentation

L-165,041 - CAS 79558-09-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

L-165,041 - CAS 79558-09-1 - Calbiochem Certificates of Analysis

TitleLot Number
422175

References

Reference overview
Rival, Y., et al. 2002. Eur. J. Pharmacol. 435, 143.
Castrillo, A., et al. 2001. J. Biol. Chem. 276, 34082.
Hansen, J.B., et al. 2001. J. Biol. Chem. 276, 3175.
Son, C., et al. 2001. Endocrinology 142, 4189.
Wilkie, N., et al. 2001. J. Neurochem. 78, 1135.
Leibowitz, M.D., et al. 2000. FEBS Lett. 473, 333.
Berger, J., et al. 1999. J. Biol. Chem. 274, 6718.
Lim, H., et al. 1999. Genes Dev. 13, 1561.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-August-2008 RFH
SynonymsCompound P, L165041, 4-[3-(2-Propyl-3-hydroxy-4-acetyl)phenoxy]propyloxyphenoxy-acetic acid, PPAR Agonist VIII, PPARα Agonist III, PPARγ Agonist VII
DescriptionA cell-permeable phenoxyacetic acid derivative that acts as a potent and selective peroxisome proliferator activator receptor δ (PPARδ) agonist (Ki = 6 nM for hPPAR δ and 730 nM for hPPARγ). Induces adipocyte differentiation in NIH-PPARδ cells at 500 nM. Also reported to raise total cholesterol in insulin-resistant db/db mice without altering glucose or triglyceride levels. Shown to increase uncoupling protein 3 (UCP3) gene expression in L6 myotubes. Also shown to inhibit cytokine-induced expression of vascular cell adhesion molecule-1 (VCAM-1) and the secretion of monocyte chemotactic protein-1 (MCP-1) in Eahy926 cells.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number79558-09-1
Chemical formulaC₂₂H₂₆O₇
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (5 mg/ml) or 1 N NaOH (40 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Irritant
ReferencesRival, Y., et al. 2002. Eur. J. Pharmacol. 435, 143.
Castrillo, A., et al. 2001. J. Biol. Chem. 276, 34082.
Hansen, J.B., et al. 2001. J. Biol. Chem. 276, 3175.
Son, C., et al. 2001. Endocrinology 142, 4189.
Wilkie, N., et al. 2001. J. Neurochem. 78, 1135.
Leibowitz, M.D., et al. 2000. FEBS Lett. 473, 333.
Berger, J., et al. 1999. J. Biol. Chem. 274, 6718.
Lim, H., et al. 1999. Genes Dev. 13, 1561.