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420345 Kaempferol - CAS 520-18-3 - Calbiochem

A cell-permeable phytoestrogen that inhibits topoisomerase I-catalyzed DNA religation in HL-60 cells.

Kaempferol - CAS 520-18-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3,4ʹ,5,7-Tetrahydroxyflavone

Primary Target: Topoisomerase I-catalyzed DNA religation in HL-60 cells
420345
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
520-18-3C₁₅H₁₀O₆

Products

Catalogue NumberPackaging Qty/Pack
420345-25MGCN Glass bottle 25 mg
Description
OverviewA cell-permeable phytoestrogen that inhibits topoisomerase I-catalyzed DNA religation in HL-60 cells. Offers protection against Aβ25-35-induced cell death in neonatal cortical neurons. Its protective effects are comparable to that of estradiol. Blocks the Aβ-induced activation of caspase-2, -3, -8, and -9, and reduces NMDA-induced neuronal apoptosis. Reported to be a potent inhibitor of monoamine oxidases. Acts as an inhibitor of COX-1 activity (IC50 = 180 µM), and of transcriptional activation of COX-2 (IC50<15 µM).
Catalogue Number420345
Brand Family Calbiochem®
Synonyms3,4ʹ,5,7-Tetrahydroxyflavone
References
ReferencesWang, C.N., et al. 2001. J. Biol. Chem. 276, 5287.
Sloley, B.D., et al. 2000. J. Pharm. Pharmacol. 52, 451.
Wang, H., et al. 2000. Phytomedicine 7, 15.
Liang, Y.C., et al. 1999. Carcinogenesis 20, 1945.
Roth, A., et al. 1999. J. Neurosci. Res. 57, 399.
Boege, F., et al. 1996. J. Biol. Chem. 271, 2262.
Constantinou, A., et al. 1995. J. Nat. Prod. 58, 217.
Product Information
CAS number520-18-3
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₅H₁₀O₆
Chemical formulaC₁₅H₁₀O₆
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetTopoisomerase I-catalyzed DNA religation in HL-60 cells
Primary Target IC<sub>50</sub>180 µM against COX-1 activity
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSLK9275200
Safety Information
R PhraseR: 36/37/38-40

Irritating to eyes, respiratory system and skin.
Limited evidence of a carcinogenic effect.
S PhraseS: 22-26-36

Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
420345-25MGCN 04055977187502

Documentation

Kaempferol - CAS 520-18-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Kaempferol - CAS 520-18-3 - Calbiochem Certificates of Analysis

TitleLot Number
420345

References

Reference overview
Wang, C.N., et al. 2001. J. Biol. Chem. 276, 5287.
Sloley, B.D., et al. 2000. J. Pharm. Pharmacol. 52, 451.
Wang, H., et al. 2000. Phytomedicine 7, 15.
Liang, Y.C., et al. 1999. Carcinogenesis 20, 1945.
Roth, A., et al. 1999. J. Neurosci. Res. 57, 399.
Boege, F., et al. 1996. J. Biol. Chem. 271, 2262.
Constantinou, A., et al. 1995. J. Nat. Prod. 58, 217.

Brochure

Title
Alzheimer's Disease Brochure & Technical Guide
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision02-January-2008 JSW
Synonyms3,4ʹ,5,7-Tetrahydroxyflavone
DescriptionA cell-permeable, phytoestrogen that offers protection against Aβ25-35-induced cell death in neonatal cortical neurons. Its protective effects are comparable to that of estradiol. Reduces the activation of caspases 2, 3, 8, and 9 by Aβ. Inhibits topoisomerase I-catalyzed DNA religation in HL-60 cells. Also shown to protect against NMDA-induced neuronal toxicity in vitro in cultured rat cortical neurons. Acts as an inhibitor of cyclooxygenases (COX-1, IC50 = 180 µM) and COX-2 (IC50 = ~15 µM).
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number520-18-3
RTECSLK9275200
Chemical formulaC₁₅H₁₀O₆
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (25 mg/ml) or Ethanol (20 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
Merck USA index14, 5274
ReferencesWang, C.N., et al. 2001. J. Biol. Chem. 276, 5287.
Sloley, B.D., et al. 2000. J. Pharm. Pharmacol. 52, 451.
Wang, H., et al. 2000. Phytomedicine 7, 15.
Liang, Y.C., et al. 1999. Carcinogenesis 20, 1945.
Roth, A., et al. 1999. J. Neurosci. Res. 57, 399.
Boege, F., et al. 1996. J. Biol. Chem. 271, 2262.
Constantinou, A., et al. 1995. J. Nat. Prod. 58, 217.