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420120 Juglone - CAS 481-39-0 - Calbiochem

A highly selective cell-permeable, irreversible inhibitor of PPlases (peptidyl-prolyl cis/trans isomerases of the parvulin family).

Juglone - CAS 481-39-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-Hydroxy-1,4-naphthlenedione, 5-Hydroxy-p-naphthoquinone

Primary Target: PPlases (peptidyl-prolyl cis/trans isomerases of the parvulin family)
420120
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
481-39-0C₁₀H₆O₃

Products

Catalogue NumberPackaging Qty/Pack
420120-250MGCN Alu drum 250 mg
Description
OverviewA highly selective cell-permeable, irreversible inhibitor of PPlases (peptidyl-prolyl cis/trans isomerases of the parvulin family). Other known PPlase inhibitors such as cyclosporin A, FK506, and rapamycin are not reported to inhibit the parvulin family of PPlases. The inactivation is shown to occur via the addition of thiol groups to juglone and not by any redox process. Exhibits bacteriostatic and fungistatic effects. Reported to be cytotoxic towards eukaryotic cells and to block transcription by RNA polymerase II.
Catalogue Number420120
Brand Family Calbiochem®
Synonyms5-Hydroxy-1,4-naphthlenedione, 5-Hydroxy-p-naphthoquinone
References
ReferencesChao, S.H., et al. 2001. Nucleic Acids Res. 29, 767.
Hennig, L., et al. 1998. Biochemistry 37, 5953.
Product Information
CAS number481-39-0
ATP CompetitiveN
FormOrange solid
Hill FormulaC₁₀H₆O₃
Chemical formulaC₁₀H₆O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPPlases (peptidyl-prolyl cis/trans isomerases of the parvulin family)
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSQJ5775000
Safety Information
R PhraseR: 36/37/38-25

Irritating to eyes, respiratory system and skin.
Toxic if swallowed.
S PhraseS: 45-26

In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
420120-250MGCN 04055977188004

Documentation

Juglone - CAS 481-39-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Juglone - CAS 481-39-0 - Calbiochem Certificates of Analysis

TitleLot Number
420120

References

Reference overview
Chao, S.H., et al. 2001. Nucleic Acids Res. 29, 767.
Hennig, L., et al. 1998. Biochemistry 37, 5953.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-May-2008 RFH
Synonyms5-Hydroxy-1,4-naphthlenedione, 5-Hydroxy-p-naphthoquinone
DescriptionOriginally isolated from the fruit shells and leaves of walnut trees, juglone is a highly selective, cell permeable, irreversible inhibitor of the parvulin family of peptidyl-prolyl cis/trans isomerases (PPIase). Functions by covalently modifying sulfhydryl groups in the target enzymes. Exhibits bacteriostatic and fungistatic properties as well as cytotoxicity in eukaryotic cells. Also reported to directly block transcription in eukaryotic cells by RNA polymerase I, II, and III as determined by nuclear run-off (IC50 = 7 µM, 7 µM, and 2 µM, respectively). Disrupts formation of functional pre-initiation complexes via modification of sulhydryl groups, but does not significantly affect initiation or elongation. Does not inhibit restriction endonucleases or T7 RNA polymerase.
FormOrange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number481-39-0
RTECSQJ5775000
Chemical formulaC₁₀H₆O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml) or Ethanol (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Toxic
Merck USA index14, 5269
ReferencesChao, S.H., et al. 2001. Nucleic Acids Res. 29, 767.
Hennig, L., et al. 1998. Biochemistry 37, 5953.