681679 Sigma-AldrichIron Chelator IV, 21H7 - Calbiochem
The Iron Chelator IV, 21H7 controls the biological activity of iron-regulated enzymes. This small molecule/inhibitor is primarily used for Cancer applications.
More>> The Iron Chelator IV, 21H7 controls the biological activity of iron-regulated enzymes. This small molecule/inhibitor is primarily used for Cancer applications. Less<<Iron Chelator IV, 21H7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 6-Bromo-Nʹ-(2-hydroxybenzylidene)-2-methylquinoline-4-carbohydrazide
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Overview
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Key Spec Table
| Empirical Formula |
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| C₁₈H₁₄BrN₃O₂ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
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| 681679-10MGCN | Glass bottle | 10 mg |
| Description | |
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| Overview | A cell-permeable salicylaldehyde-acylhydrazone iron chelator that is 20-times more efficient than DFO/desferrioxamine (Cat. No. 252750) in depleting intracellular iron in colon cancer SW480 cells. Iron chelators exert their biological activities by affecting iron-regulated enzymes and singaling events, including HIF1α transcription activation due to inhibition of PHD- (prolyl hydroxylase) mediated HIF1α degradation, as well as altered mRNA translations due to enhanced IRP (Iron Regulatory Protein) IREs (Iron Response Elements) binding. Cellular iron depletion is also reported to inhibit the growths of colorectal adenocarcinoma cultures, DLD-1 (IC50 = 0.6 and 2.9 µM, respectively, by 21H7 and DFO) and SW480 (IC50 = 1.0 and 3.8 µM, respectively, by 21H7 and DFO), as a result of Wnt signaling pathway blockage (Effective conc. = 5 µM 21H7 or 100 µM DFO). |
| Catalogue Number | 681679 |
| Brand Family | Calbiochem® |
| Synonyms | 6-Bromo-Nʹ-(2-hydroxybenzylidene)-2-methylquinoline-4-carbohydrazide |
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| References | Song, S., et al. 2011. Cancer Res. 71, 7628. |
| Product Information | |
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| Form | Off-white solid |
| Hill Formula | C₁₈H₁₄BrN₃O₂ |
| Chemical formula | C₁₈H₁₄BrN₃O₂ |
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| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥97% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 681679-10MGCN | 04055977225266 |
Documentation
Iron Chelator IV, 21H7 - Calbiochem SDS
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Iron Chelator IV, 21H7 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 681679 |
References
| Reference overview |
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| Song, S., et al. 2011. Cancer Res. 71, 7628. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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