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407950 Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem

Ionomycin, Free Acid, Streptomyces conglobatus, CAS 56092-81-0, is an ionophore with high specificity for divalent cations. More effective than A23187 as a mobile ion carrier for Ca2+.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
407950
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Overview

Key Spec Table

CAS #Empirical Formula
56092-81-0C₄₁H₇₂O₉

Products

Catalogue NumberPackaging Qty/Pack
407950-10MGCN Plastic ampoule 10 mg
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407950-1MGCN Plastic ampoule 1 mg
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407950-5MGCN Plastic ampoule 5 mg
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Description
OverviewHighly specific for divalent cations and more effective than A23187 (Cat. No. 100105) as a mobile ion carrier for Ca2+. Complexes with Ca2+ between pH 7 and 9.5. In contrast to A23187, it is not fluorescent. Useful for studies of Ca2+ transport across biological membranes and measurement of cytoplasmic free Ca2+. Induces apoptotic neuronal degeneration in embryonic cortical neurons and cell cycle arrest in the G1 phase in mature Burkitt lymphoma cell lines.
Absorption max. (280 nm, MeOH): 18,600 M-1cm-1.
Catalogue Number407950
Brand Family Calbiochem®
References
ReferencesAagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol. 155, 3297.
Takei, N., and Endo, Y. 1994. Brain Res. 652, 65.
Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol. 154, 44.
Lee, H.C. 1993. J. Biol. Chem. 268, 293.
Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932.
Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc. 101, 3344.
Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem. 253, 5892.
Product Information
CAS number56092-81-0
ATP CompetitiveN
FormWaxy solid
Hill FormulaC₄₁H₇₂O₉
Chemical formulaC₄₁H₇₂O₉
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationIonomycin, Free Acid, Streptomyces conglobatus, CAS 56092-81-0, is an ionophore with high specificity for divalent cations. More effective than A23187 as a mobile ion carrier for Ca2+.
Biological Information
Primary TargetMobile ion carrier for Ca2+
Purity≥90% by HPLC
Physicochemical Information
Cell permeableN
Safety Information according to GHS
RTECSNO0600000
Safety Information
R PhraseR: 22

Harmful if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 year at 4°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
407950-10MGCN 04055977211566
407950-1MGCN 04055977211559
407950-5MGCN 04055977211573