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407950 Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem

Ionomycin, Free Acid, Streptomyces conglobatus, CAS 56092-81-0, is an ionophore with high specificity for divalent cations. More effective than A23187 as a mobile ion carrier for Ca2+.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
407950
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
56092-81-0C₄₁H₇₂O₉

Products

Catalogue NumberPackaging Qty/Pack
407950-10MGCN Plastic ampoule 10 mg
407950-1MGCN Plastic ampoule 1 mg
407950-5MGCN Plastic ampoule 5 mg
Description
OverviewHighly specific for divalent cations and more effective than A23187 (Cat. No. 100105) as a mobile ion carrier for Ca2+. Complexes with Ca2+ between pH 7 and 9.5. In contrast to A23187, it is not fluorescent. Useful for studies of Ca2+ transport across biological membranes and measurement of cytoplasmic free Ca2+. Induces apoptotic neuronal degeneration in embryonic cortical neurons and cell cycle arrest in the G1 phase in mature Burkitt lymphoma cell lines.
Absorption max. (280 nm, MeOH): 18,600 M-1cm-1.
Catalogue Number407950
Brand Family Calbiochem®
References
ReferencesAagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol. 155, 3297.
Takei, N., and Endo, Y. 1994. Brain Res. 652, 65.
Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol. 154, 44.
Lee, H.C. 1993. J. Biol. Chem. 268, 293.
Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932.
Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc. 101, 3344.
Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem. 253, 5892.
Product Information
CAS number56092-81-0
ATP CompetitiveN
FormWaxy solid
Hill FormulaC₄₁H₇₂O₉
Chemical formulaC₄₁H₇₂O₉
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationIonomycin, Free Acid, Streptomyces conglobatus, CAS 56092-81-0, is an ionophore with high specificity for divalent cations. More effective than A23187 as a mobile ion carrier for Ca2+.
Biological Information
Primary TargetMobile ion carrier for Ca2+
Purity≥90% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSNO0600000
Safety Information
R PhraseR: 22

Harmful if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 year at 4°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
407950-10MGCN 04055977211566
407950-1MGCN 04055977211559
407950-5MGCN 04055977211573

Documentation

Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem Certificates of Analysis

TitleLot Number
407950

References

Reference overview
Aagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol. 155, 3297.
Takei, N., and Endo, Y. 1994. Brain Res. 652, 65.
Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol. 154, 44.
Lee, H.C. 1993. J. Biol. Chem. 268, 293.
Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932.
Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc. 101, 3344.
Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem. 253, 5892.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure

Citations

Title
  • Jonathan Rios-Doria, et al. (2004) Cleavage of b-catenin by calpain in prostate and mammary tumor cells. Cancer Research 64, 7237-7240.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision16-April-2010 JSW
    DescriptionHighly specific for divalent cations (Ca2+ > Mg2+ >> Sr2+ = Ba2+). More effective than antibiotic A23187 as a mobile ion carrier for Ca2+. Complexes with Ca2+ between pH 7 and 9.5, causing significant absorption in the UV range; however, in contrast to A23187 (Cat. No. 100105), it is not fluorescent. Useful for studies of Ca2+ transport across biological membranes and measurement of cytoplasmic free Ca2+. Induces apoptotic neuronal degeneration in embryonic cortical neurons. Also induces cell cycle arrest in the G1 interval of mature Burkitt lymphoma cell lines.
    FormWaxy solid
    Intert gas (Yes/No) Packaged under inert gas
    CAS number56092-81-0
    RTECSNO0600000
    Chemical formulaC₄₁H₇₂O₉
    Structure formulaStructure formula
    Purity≥90% by HPLC
    SolubilityDMSO (10 mg/ml) and Methanol (10 mg/ml)
    Storage Protect from light
    +2°C to +8°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 year at 4°C.
    Toxicity Harmful
    ReferencesAagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol. 155, 3297.
    Takei, N., and Endo, Y. 1994. Brain Res. 652, 65.
    Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol. 154, 44.
    Lee, H.C. 1993. J. Biol. Chem. 268, 293.
    Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932.
    Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc. 101, 3344.
    Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem. 253, 5892.
    Citation
  • Jonathan Rios-Doria, et al. (2004) Cleavage of b-catenin by calpain in prostate and mammary tumor cells. Cancer Research 64, 7237-7240.
    		•