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506148 InSolution™ p38 MAP Kinase Inhibitor III - Calbiochem

InSolution p38 MAP Kinase Inhibitor III, CAS 581098-48-8, is a 10 mM solution in DMSO. A cell-permeable, potent, selective, ATP-competitive p38 MAP kinase inhibitor (IC50 = 380 nM for p38α).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: p38 MAP kinase
506148
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₃H₂₁FN₄S

Products

Catalogue NumberPackaging Qty/Pack
506148-1MGCN Plastic ampoule 1 mg
Description
Catalogue Number506148
Brand Family Calbiochem®
References
ReferencesLaufer, S.A., et al. 2003. J. Med. Chem. 46, 3230.
Product Information
ATP CompetitiveY
FormLiquid
FormulationA 10 mM (1 mg/247 µl) solution of p38 MAP Kinase Inhibitor III (Cat. No. 506121) in DMSO.
Hill FormulaC₂₃H₂₁FN₄S
Chemical formulaC₂₃H₂₁FN₄S
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationInSolution p38 MAP Kinase Inhibitor III, CAS 581098-48-8, is a 10 mM solution in DMSO. A cell-permeable, potent, selective, ATP-competitive p38 MAP kinase inhibitor (IC50 = 380 nM for p38α).
Biological Information
Primary Targetp38 MAP kinase
Primary Target IC<sub>50</sub>0.38 µM for p38α; 0.16 and 0.039 µM in suppressing LPS-induced TNF-α and IL-1β release, respectively, in human PBMC; ED50 = 1.33 mg/kg in suppressing LPS-induced TNF-α release in mouse
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
506148-1MGCN 04055977272215

Documentation

InSolution™ p38 MAP Kinase Inhibitor III - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ p38 MAP Kinase Inhibitor III - Calbiochem Certificates of Analysis

TitleLot Number
506148

References

Reference overview
Laufer, S.A., et al. 2003. J. Med. Chem. 46, 3230.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-August-2008 RFH
DescriptionA cell-permeable, potent, selective, and ATP-competitive inhibitor of p38 MAP kinase (IC50 = 380 nM for p38α). Shown to effectively suppress LPS-induced cytokine release in vitro (IC50 = 160 nM for TNF-α release and 39 nM for IL-1β release, human PBMC) and in vivo (ED50 = 1.33 mg/kg for TNF-α release in mice). Exhibits reduced inhibitory activity against cytochrome P450-2D6 compared to SB 203580 (Cat. No 559389) and is better suited for use in animal models.
FormLiquid
FormulationA 10 mM (1 mg/247 µl) solution of p38 MAP Kinase Inhibitor III (Cat. No. 506121) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₃H₂₁FN₄S
Structure formulaStructure formula
Purity≥98% by HPLC
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
Toxicity Standard Handling
ReferencesLaufer, S.A., et al. 2003. J. Med. Chem. 46, 3230.