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539749 InSolution™ PTP1B Inhibitor - Calbiochem

The InSolution™ PTP1B Inhibitor controls the biological activity of PTP1B. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

InSolution™ PTP1B Inhibitor - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PTP Inhibitor XXII

539749
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₆H₁₉Br₂N₃O₇S₃

Products

Catalogue NumberPackaging Qty/Pack
539749-2MGCN Glass bottle 2 mg
Description
OverviewA cell-permeable, selective, reversible, and non-competitive allosteric inhibitor of PTP1B (IC50 = 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively). Binds to a novel site away from the catalytic pocket and inhibits PTP1B activity by preventing closure of the WPD loop.
Catalogue Number539749
Brand Family Calbiochem®
SynonymsPTP Inhibitor XXII
References
ReferencesWiesmann, C., et al. 2004. Nat. Struct. Mol. Biol. 11, 730.
Product Information
FormLiquid
FormulationA 10 mM (2 mg/270 µl) solution of PTP1B Inhibitor (Cat. No. 539741) in DMSO.
Hill FormulaC₂₆H₁₉Br₂N₃O₇S₃
Chemical formulaC₂₆H₁₉Br₂N₃O₇S₃
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target IC<sub>50</sub>IC50 = 4 and 8 µM for PTP1B403 and PTP1B298, respectively
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
539749-2MGCN 04055977194364

Documentation

InSolution™ PTP1B Inhibitor - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ PTP1B Inhibitor - Calbiochem Certificates of Analysis

TitleLot Number
539749

References

Reference overview
Wiesmann, C., et al. 2004. Nat. Struct. Mol. Biol. 11, 730.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision22-November-2011 RFH
SynonymsPTP Inhibitor XXII
DescriptionA cell-permeable, selective, reversible, and non-competitive allosteric inhibitor of PTP1B (IC50 = 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively). Binds to a novel site away from the catalytic pocket and inhibits PTP1B activity by preventing closure of the WPD loop.
FormLiquid
FormulationA 10 mM (2 mg/270 µl) solution of PTP1B Inhibitor (Cat. No. 539741) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₆H₁₉Br₂N₃O₇S₃
Structure formulaStructure formula
Purity≥97% by HPLC
Storage Protect from light
Avoid freeze/thaw
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Irritant
ReferencesWiesmann, C., et al. 2004. Nat. Struct. Mol. Biol. 11, 730.