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440204 InSolution™ LY 294002 - CAS 154447-36-6 - Calbiochem

InSolution™ LY 294002, CAS 154447-36-6, is a 10 mM solution of LY 294002 (Cat. No. 440202) in DMSO. A cell-permeable, potent, reversible and specific inhibitor of PI 3-kinase (IC50 = 1.4 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor IV, BRD3 Inhibitor III, BRD4 Inhibitor IV

Primary Target: phosphatidylinositol 3-kinase
440204
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
154447-36-6C₁₉H₁₇NO₃

Products

Catalogue NumberPackaging Qty/Pack
440204-1MGCN Plastic ampoule 1 mg
Description
Catalogue Number440204
Brand Family Calbiochem®
Synonyms2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor IV, BRD3 Inhibitor III, BRD4 Inhibitor IV
References
ReferencesDittman, A., et al. 2013. ACS Chem. Biol. 9, 495.
Baumann, P., and West, S.C. 1998. Proc. Natl. Acad. Sci. USA 95, 14066.
Cardone, M.H., et al. 1998. Science 282, 1318.
Vlahos, C.J., et al. 1995. J. Immunol. 154, 2413.
Yano, H., et al. 1995. Biochem. J. 312, 145.
Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.



Selected Citations
Lee, J., et al. 2009. Cell Stem Cell 5, 76.
Product Information
CAS number154447-36-6
ATP CompetitiveY
FormLiquid
FormulationA 10 mM (1 mg/325 µl) solution of LY 294002 (Cat. No. 440202) in DMSO.
Hill FormulaC₁₉H₁₇NO₃
Chemical formulaC₁₉H₁₇NO₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationInSolution™ LY 294002, CAS 154447-36-6, is a 10 mM solution of LY 294002 (Cat. No. 440202) in DMSO. A cell-permeable, potent, reversible and specific inhibitor of PI 3-kinase (IC50 = 1.4 µM).
Biological Information
Primary Targetphosphatidylinositol 3-kinase
Primary Target IC<sub>50</sub>1.4 µM against phosphatidylinositol 3-kinase
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26-36-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
440204-1MGCN 04055977186710

Documentation

InSolution™ LY 294002 - CAS 154447-36-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ LY 294002 - CAS 154447-36-6 - Calbiochem Certificates of Analysis

TitleLot Number
440204

References

Reference overview
Dittman, A., et al. 2013. ACS Chem. Biol. 9, 495.
Baumann, P., and West, S.C. 1998. Proc. Natl. Acad. Sci. USA 95, 14066.
Cardone, M.H., et al. 1998. Science 282, 1318.
Vlahos, C.J., et al. 1995. J. Immunol. 154, 2413.
Yano, H., et al. 1995. Biochem. J. 312, 145.
Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.



Selected Citations
Lee, J., et al. 2009. Cell Stem Cell 5, 76.

Citations

Title
  • Ana Olivera, et al. (2006) IgE-dependent activation of sphingosine kinase 1 and 2 and secretion of sphingosine-1-phosphate requires Fyn kinase and contributes to mast cell responses. Journal of Biological Chemistry 281, 2515-2525.
  • Huanyu Dou, et al. (2005) Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. Journal of Neuroscience 25, 8375-8385.
  • Julie Lotharius, et al. (2005) Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed lineage kinase pathway. Journal of Neuroscience 25, 6329-6342.
  • Meenalakshmi M. Mariappan, et al. (2005) Phospholipase Cγ-Erk Axis in Vascular Endothelial Growth Factor-Induced Eukaryotic Initiation Factor 4E Phosphorylation and Protein Synthesis in Renal Epithelial Cells. Journal of Biological Chemistry 280, 28402-28411.
  • Michael Tscharntke, et al. (2005) Ras-induced spreading and wound closure in human epidermal keratinocytes. The FASEB Journal in press,.
  • Junji Tsurutani, et al. (2005) Inhibition of the phosphatidylinositol 3-kinase/Akt/Mammalian target of rapamycin pathway but no the MEK/ERK Pathway attentuates laminin-meidated small cell lunch cancer cellular survival and resistance to Imatinib mesylate or chemolyte.. Cancer Research 65, 8423-8432.
  • Xinbo Liao, et al. (2003) Androgen stimulates matrix metalloproteinase-2 expression in human prostate cancer. Endocrinology 144, 1656-1663.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision06-August-2008 RFH
    Synonyms2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor IV, BRD3 Inhibitor III, BRD4 Inhibitor IV
    FormLiquid
    FormulationA 10 mM (1 mg/325 µl) solution of LY 294002 (Cat. No. 440202) in DMSO.
    Intert gas (Yes/No) Packaged under inert gas
    CAS number154447-36-6
    Chemical formulaC₁₉H₁₇NO₃
    Structure formulaStructure formula
    Purity≥98% by HPLC
    Storage Protect from light
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
    Toxicity Irritant
    ReferencesDittman, A., et al. 2013. ACS Chem. Biol. 9, 495.
    Baumann, P., and West, S.C. 1998. Proc. Natl. Acad. Sci. USA 95, 14066.
    Cardone, M.H., et al. 1998. Science 282, 1318.
    Vlahos, C.J., et al. 1995. J. Immunol. 154, 2413.
    Yano, H., et al. 1995. Biochem. J. 312, 145.
    Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.



    Selected Citations
    Lee, J., et al. 2009. Cell Stem Cell 5, 76.
    Citation
  • Ana Olivera, et al. (2006) IgE-dependent activation of sphingosine kinase 1 and 2 and secretion of sphingosine-1-phosphate requires Fyn kinase and contributes to mast cell responses. Journal of Biological Chemistry 281, 2515-2525.
  • Huanyu Dou, et al. (2005) Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. Journal of Neuroscience 25, 8375-8385.
  • Julie Lotharius, et al. (2005) Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed lineage kinase pathway. Journal of Neuroscience 25, 6329-6342.
  • Meenalakshmi M. Mariappan, et al. (2005) Phospholipase Cγ-Erk Axis in Vascular Endothelial Growth Factor-Induced Eukaryotic Initiation Factor 4E Phosphorylation and Protein Synthesis in Renal Epithelial Cells. Journal of Biological Chemistry 280, 28402-28411.
  • Michael Tscharntke, et al. (2005) Ras-induced spreading and wound closure in human epidermal keratinocytes. The FASEB Journal in press,.
  • Junji Tsurutani, et al. (2005) Inhibition of the phosphatidylinositol 3-kinase/Akt/Mammalian target of rapamycin pathway but no the MEK/ERK Pathway attentuates laminin-meidated small cell lunch cancer cellular survival and resistance to Imatinib mesylate or chemolyte.. Cancer Research 65, 8423-8432.
  • Xinbo Liao, et al. (2003) Androgen stimulates matrix metalloproteinase-2 expression in human prostate cancer. Endocrinology 144, 1656-1663.
    		•