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420097 InSolution™ JAK Inhibitor I - CAS 457081-03-7 - Calbiochem

InSolution™ JAK Inhibitor I, CAS 457081-03-7, is a 10 mM solution in DMSO. A highly potent, ATP-competitive inhibitor of JAK. (IC50 = 15, 1, 5 & 1 nM for JAK1, 2, 3 & Tyk2, respectively).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, P6, Pyridone 6, DBI, JAK1 Inhibitor I, JAK2 Inhibitor I, JAK3 Inhibitor X

Primary Target: murine JAK1
420097
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
457081-03-7C₁₈H₁₆FN₃O

Products

Catalogue NumberPackaging Qty/Pack
420097-500UGCN Plastic ampoule 500 μg
Description
Catalogue Number420097
Brand Family Calbiochem®
Synonyms2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, P6, Pyridone 6, DBI, JAK1 Inhibitor I, JAK2 Inhibitor I, JAK3 Inhibitor X
References
ReferencesThompson, J.E., et al. 2002. Bioorg. Med. Chem. Lett. 12, 1219.
Product Information
CAS number457081-03-7
ATP CompetitiveY
FormLiquid
FormulationA 10 mM (500 µg/162 µl) solution of JAK Inhibitor I (Cat. No. 420099) in DMSO.
Hill FormulaC₁₈H₁₆FN₃O
Chemical formulaC₁₈H₁₆FN₃O
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationInSolution™ JAK Inhibitor I, CAS 457081-03-7, is a 10 mM solution in DMSO. A highly potent, ATP-competitive inhibitor of JAK. (IC50 = 15, 1, 5 & 1 nM for JAK1, 2, 3 & Tyk2, respectively).
Biological Information
Primary Targetmurine JAK1
Primary Target IC<sub>50</sub>15 nM, 1 nM against murine JAK1 and JAK2, respectively; 1 nM against Tyk2
Primary Target K<sub>i</sub> 5 nM against JAK3
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
420097-500UGCN 04055977187861

Documentation

InSolution™ JAK Inhibitor I - CAS 457081-03-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ JAK Inhibitor I - CAS 457081-03-7 - Calbiochem Certificates of Analysis

TitleLot Number
420097

References

Reference overview
Thompson, J.E., et al. 2002. Bioorg. Med. Chem. Lett. 12, 1219.

Technical Info

Title
JAK/STAT Signaling Research Focus
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-February-2009 JSW
Synonyms2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, P6, Pyridone 6, DBI, JAK1 Inhibitor I, JAK2 Inhibitor I, JAK3 Inhibitor X
DescriptionA potent inhibitor of Janus Protein tyrosine Kinases (JAKs). Displays potent inhibitory activity against JAK1 (IC50 = 15 nM for murine JAK1), JAK2 IC50 = 1 nM), JAK3 (Ki = 5 nM), and Tyk2 (IC50 = 1 nM). It inhibits other kinases only at much higher concentrations. Also inhibits IL-2- and IL-4-dependent proliferation of CTLL cells and blocks the phosphorylation of STAT5.
FormLiquid
FormulationA 10 mM (500 µg/162 µl) solution of JAK Inhibitor I (Cat. No. 420099) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
CAS number457081-03-7
Chemical formulaC₁₈H₁₆FN₃O
Structure formulaStructure formula
Purity≥98% by HPLC
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
Toxicity Irritant
ReferencesThompson, J.E., et al. 2002. Bioorg. Med. Chem. Lett. 12, 1219.