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658548 InSolution™ AG 1478 - CAS 175178-82-2 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Epidermal growth factor receptor kinase
658548
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
175178-82-2C₁₆H₁₄ClN₃O₂

Products

Catalogue NumberPackaging Qty/Pack
658548-1MGCN Plastic ampoule 1 mg
Description
Catalogue Number658548
Brand Family Calbiochem®
References
ReferencesLevitski, A., and Gazit, A. 1995. Science 267, 1782.
Fry, D.W., et al. 1994. Science 265, 1093.
Osherov, N., and Levitski, A. 1994. Eur. J. Biochem. 225, 1047.
Ward, W.H., et al. 1994. Biochem. Pharmacol. 48, 659.
Product Information
CAS number175178-82-2
ATP CompetitiveY
DeclarationSold under license of U.S. Patent 5,457,105 and European Patent 0,566,266.
FormClear to faint tan liquid
FormulationA 10 mM (1 mg/317 µl) solution of AG 1478 (Cat. No. 658552) in DMSO.
Hill FormulaC₁₆H₁₄ClN₃O₂
Chemical formulaC₁₆H₁₄ClN₃O₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetEpidermal growth factor receptor kinase
Primary Target IC<sub>50</sub>3 nM against of epidermal growth factor receptor kinase
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
658548-1MGCN 04055977261646

Documentation

InSolution™ AG 1478 - CAS 175178-82-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ AG 1478 - CAS 175178-82-2 - Calbiochem Certificates of Analysis

TitleLot Number
658548

References

Reference overview
Levitski, A., and Gazit, A. 1995. Science 267, 1782.
Fry, D.W., et al. 1994. Science 265, 1093.
Osherov, N., and Levitski, A. 1994. Eur. J. Biochem. 225, 1047.
Ward, W.H., et al. 1994. Biochem. Pharmacol. 48, 659.

Citations

Title
  • Farahdiba Jafri, et al. (2006) Constitutive ERK1/2 activation by a chimeric neurokinin NK1 receptor-beta-arrestin1 fusion protein: Probing the composition and function of the G protein-coupled receptor 'signalsome'. Journal of Biological Chemistry in press,.
  • Ying-Hong Feng, et al. (2005) Unconventional Homologous Internalization of the Angiotensin II Type-1 Receptor Induced by G-Protein-Independent Signals. Hypertension 46, 419-423.
  • Diane Gesty-Palmer, et al. (2005) b-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts. Journal of Biological Chemistry 280, 32157-32167.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision15-September-2008 RFH
    DescriptionHighly potent and specific inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (IC50 = 3 nM). Much higher concentrations are required for inhibition of the kinase activity of the closely related HER2 (neu/erb-B2) receptor (IC50 > 100 µM), the platelet-derived growth factor (PDGF) receptor (IC50 > 100 µM), and p210Bcr-Abl (IC50 >50 µM). Its mechanism of inhibition likely mimics that of the related compound, 4-(3-chloroanilino)quinazoline (CAQ), a competitive inhibitor with respect to ATP.
    FormClear to faint tan liquid
    FormulationA 10 mM (1 mg/317 µl) solution of AG 1478 (Cat. No. 658552) in DMSO.
    Intert gas (Yes/No) Packaged under inert gas
    CAS number175178-82-2
    Chemical formulaC₁₆H₁₄ClN₃O₂
    Structure formulaStructure formula
    Purity≥98% by HPLC
    Storage Protect from light
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
    Toxicity Irritant
    ReferencesLevitski, A., and Gazit, A. 1995. Science 267, 1782.
    Fry, D.W., et al. 1994. Science 265, 1093.
    Osherov, N., and Levitski, A. 1994. Eur. J. Biochem. 225, 1047.
    Ward, W.H., et al. 1994. Biochem. Pharmacol. 48, 659.
    Citation
  • Farahdiba Jafri, et al. (2006) Constitutive ERK1/2 activation by a chimeric neurokinin NK1 receptor-beta-arrestin1 fusion protein: Probing the composition and function of the G protein-coupled receptor 'signalsome'. Journal of Biological Chemistry in press,.
  • Ying-Hong Feng, et al. (2005) Unconventional Homologous Internalization of the Angiotensin II Type-1 Receptor Induced by G-Protein-Independent Signals. Hypertension 46, 419-423.
  • Diane Gesty-Palmer, et al. (2005) b-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts. Journal of Biological Chemistry 280, 32157-32167.
    		•