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12-459 IKK Substrate Peptide

IKK Substrate Peptide MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
12-459
1 mg  
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue Number12-459
Brand Family Upstate
Trade Name
  • Upstate
DescriptionIKK Substrate Peptide
References
Product Information
PresentationLyophilized powder
Quality LevelMQ100
Applications
Key Applications
  • Kinase Assay
Biological Information
Entrez Gene Number
Entrez Gene SummaryThis gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.
Gene Symbol
  • CHUK
  • NFKBIKA
  • IKKA
  • IKBKA
  • IkBKA
  • TCF16
  • IKK1
  • IKK-A
  • IKK-alpha
Protein TargetIKKα
Target Sub-FamilyMisc
UniProt Number
UniProt SummaryFUNCTION: SwissProt: O15111 # Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B- regulated promoters during inflammatory responses triggered by cytokines.
SIZE: 745 amino acids; 84654 Da
SUBUNIT: Preferentially found as a heterodimer with IKK-beta but also as an homodimer. Directly interacts with IKK-gamma/NEMO and TRPC4AP (By similarity). Heterodimers form the active complex. The tripartite complex can also bind to MAP3K14/NIK, MEKK1, IKAP and IKB-alpha-p65-p50 complex. A weak interaction with TRAF2 cannot be excluded. Part of a complex composed of NCOA2, NCOA3, IKKB, IKBKG and CREBBP. Interacts with NALP2. May interact with MAVS/IPS1.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus.
TISSUE SPECIFICITY: Widely expressed.
PTM: Phosphorylated by MAP3K14/NIK, AKT and to a lesser extent by MEKK1, and dephosphorylated by PP2A. Autophosphorylated.
SIMILARITY: SwissProt: O15111 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. IkappaB kinase subfamily. & Contains 1 protein kinase domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated as a substrate for IKKα (Catalog #14-461) and IKKβ (Catalog #14-485)
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsLyophilized: 2 years at 4°C; Rehydrated: 6 months at -20°C
Packaging Information
Material Size1 mg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
12-459 04053252736889

Documentation

IKK Substrate Peptide SDS

Title

Safety Data Sheet (SDS) 

IKK Substrate Peptide Certificates of Analysis

TitleLot Number
IKK Substrate Peptide 2477133
IKK Substrate Peptide (IKKtide) - 2450018 2450018
IKK Substrate Peptide (IKKtide) 3153995
IKK Substrate Peptide (IKKtide) 3025906
IKK Substrate Peptide (IKKtide) - 2243483 2243483
IKK Substrate Peptide (IKKtide) - 3227032 3227032
IKK Substrate Peptide (IKKtide) - 3379918 3379918
IKK Substrate Peptide - 22357 22357
IKK Substrate Peptide - 26004 26004
IKK Substrate Peptide - 26004A 26004A
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Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Kinase & Phosphatase Substrates
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Kinase & Phosphatase Substrates