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401477 IκB Kinase Inhibitor Peptide, Cell-Permeable - Calbiochem

The IκB Kinase Inhibitor Peptide, Cell-Permeable controls the biological activity of IκB Kinase. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ac-AAVALLPAVLLALLAPDDRHDSGLDSMKDE-NH₂

Primary Target: LPS-induced IκB degradation by IKK in RAW 264.7 cells
401477
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₃₈H₂₂₉N₃₇O₄₅S

Products

Catalogue NumberPackaging Qty/Pack
401477-1MGCN Plastic ampoule 1 mg
Description
OverviewA 14-amino acid peptide corresponding to the active IκB phosphorylation recognition sequence fused to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Specifically inhibits LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells (< 50 µg/ml) and prevents NF-κB activation. Supplied as a trifluoroacetate salt.
Catalogue Number401477
Brand Family Calbiochem®
SynonymsAc-AAVALLPAVLLALLAPDDRHDSGLDSMKDE-NH₂
References
ReferencesSwaroop, N., et al. 2001. Pharm. Res. 18, 1631.
Traenckner, E.B., et al. 1995. EMBO. J. 14, 2876.
Product Information
ATP CompetitiveN
FormLyophilized
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₁₃₈H₂₂₉N₃₇O₄₅S
Chemical formulaC₁₃₈H₂₂₉N₃₇O₄₅S
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetLPS-induced IκB degradation by IKK in RAW 264.7 cells
Primary Target IC<sub>50</sub><50 µg/ml for inhibiting LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells and prevents NF-κB activation
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Asp-Arg-His-Asp-Ser-Gly-Leu-Asp-Ser-Met-Lys-Asp-Glu-NH₂
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
401477-1MGCN 04055977211924

Documentation

IκB Kinase Inhibitor Peptide, Cell-Permeable - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

IκB Kinase Inhibitor Peptide, Cell-Permeable - Calbiochem Certificates of Analysis

TitleLot Number
401477

References

Reference overview
Swaroop, N., et al. 2001. Pharm. Res. 18, 1631.
Traenckner, E.B., et al. 1995. EMBO. J. 14, 2876.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-September-2007 RFH
SynonymsAc-AAVALLPAVLLALLAPDDRHDSGLDSMKDE-NH₂
DescriptionA 14-amino acid peptide corresponding to the active IκB phosphorylation recognition sequence, linked to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Specifically inhibits LPS-induced IκB degradation by IkB kinases (IKK) in RAW 264.7 cells (<50 μg/ml) and prevents NF-κB activation.
FormLyophilized
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₃₈H₂₂₉N₃₇O₄₅S
Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Asp-Arg-His-Asp-Ser-Gly-Leu-Asp-Ser-Met-Lys-Asp-Glu-NH₂
Purity≥95% by HPLC
SolubilityPBS, pH 7.4 (1 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSwaroop, N., et al. 2001. Pharm. Res. 18, 1631.
Traenckner, E.B., et al. 1995. EMBO. J. 14, 2876.