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400084 HIF Prolyl Hydroxylase Inhibitor - CAS 385786-48-1 - Calbiochem

400084
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Overview

Key Spec Table

CAS #Empirical Formula
385786-48-1C₂₁H₁₆ClN₃O₂

Products

Catalogue NumberPackaging Qty/Pack
400084-10MGCN Glass bottle 10 mg
Description
OverviewA cell-permeable, hydroxyquinoline HIF Prolyl Hydroxylase (PHD) inhibitor that displays an IC50 = 2 µM in a cell-based assay using a reporter produced by fusing HIF-1α oxygen degradable domain (ODD) to luciferase. This compound (5 µM) is shown to significantly stabilize HIF-1α in vitro and upregulate known HIF target genes, Epo and VEGF, in SH-SY5Y human neuroblastoma cell lines. It also exerts a neuroprotective effect (IC50 = 0.25 µM in an oxidative stress model using cortical neurons.
Catalogue Number400084
Brand Family Calbiochem®
SynonymsAdaptaquin
References
ReferencesSmirnova, N.A., et al. 2010. Chem. Biol. 4, 380.
Product Information
CAS number385786-48-1
FormTan solid
Hill FormulaC₂₁H₁₆ClN₃O₂
Chemical formulaC₂₁H₁₆ClN₃O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥95% by HPLC
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Global Trade Item Number
Catalogue Number GTIN
400084-10MGCN 04055977212327