345834 Sigma-AldrichGenistein, Soybean - CAS 446-72-0 - Calbiochem
A cell-permeable, reversible, substrate competitive inhibitor of protein tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC₅₀ = 2.6 µM).
More>> A cell-permeable, reversible, substrate competitive inhibitor of protein tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC₅₀ = 2.6 µM). Less<<Synonyms: 4ʹ,5,7-Trihydroxyisoflavone
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Overview
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Key Spec Table
CAS # | Empirical Formula |
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446-72-0 | C₁₅H₁₀O₅ |
Products
Catalogue Number | Packaging | Qty/Pack | |
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345834-20MGCN | Glass bottle | 20 mg | |
345834-50MGCN | Plastic ampoule | 50 mg |
Product Information | |
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CAS number | 446-72-0 |
ATP Competitive | N |
Form | White solid |
Hill Formula | C₁₅H₁₀O₅ |
Chemical formula | C₁₅H₁₀O₅ |
Reversible | Y |
Structure formula Image | |
Quality Level | MQ100 |
Applications |
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Biological Information | |
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Primary Target | EGFR kinase |
Primary Target IC<sub>50</sub> | 2.6 µM against autophosphorylation of epidermal growth factor receptor kinase |
Purity | ≥95% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
Dimensions |
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Materials Information |
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Toxicological Information |
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Safety Information according to GHS | |
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RTECS | NR2392000 |
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Supplemental Information |
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Specifications |
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Global Trade Item Number | |
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Catalogue Number | GTIN |
345834-20MGCN | 04055977214376 |
345834-50MGCN | 04055977214383 |
Documentation
Genistein, Soybean - CAS 446-72-0 - Calbiochem SDS
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Genistein, Soybean - CAS 446-72-0 - Calbiochem Certificates of Analysis
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345834 |
References
Reference overview |
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Constantinou, A., and Huberman, E. 1995. Proc. Soc. Exp. Biol. Med. 208, 109. Wei, H., et al. 1995. Proc. Soc. Exp. Biol. Med. 208, 124. Wei, H., et al. 1995. Carcinogenesis 17, 73. Kobayashi, S., et al. 1994. J. Biol. Chem. 269, 9011. Migita, K., et al. 1994. J. Immunol. 153, 3457. Spinozzi, F., et al. 1994. Leuk. Res. 18, 431. Dhar, A., et al. 1990. Mol. Pharmacol. 37, 519. Hill, T.D., et al. 1990. Science 248, 1660. Dean, N.M., et al. 1989. Biochem. Biophys. Res. Commun. 165, 795. Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592. |
Brochure
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Caspases and other Apoptosis Related Tools Brochure |
Citations
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