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361553 GSK-3β Inhibitor XI - CAS 626604-39-5 - Calbiochem

The GSK-3β Inhibitor XI, also referenced under CAS 626604-39-5, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(1-(3-Hydroxypropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-pyrazin-2-yl-pyrrole-2,5-dione, 7AIPM

Primary Target: Gsk-3β
361553
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
626604-39-5C₁₈H₁₅N₅O₃

Products

Catalogue NumberPackaging Qty/Pack
361553-1MGCN Plastic ampoule 1 mg
Description
OverviewA cell-permeable azaindolylmaleimide compound that acts as a potent, specific, and ATP-competitive inhibitor of GSK-3β (Ki = 25 nM) and minimally inhibits a panel of 79 commonly studied protein kinases, including several PKC isozymes. Shown to increase intracellular glycogen synthase activity in HEK293 cells with an EC50 of 32 nM and demonstrate metabolic stability in human liver microsomes (HLM; t1/2 > 100 min).
Catalogue Number361553
Brand Family Calbiochem®
Synonyms3-(1-(3-Hydroxypropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-pyrazin-2-yl-pyrrole-2,5-dione, 7AIPM
References
ReferencesJustman, Q.A., et al. 2009. Science 324, 509.
O'Neill, D.J., et al. 2004. Bioorg. Med. Chem. 12, 3167.
Product Information
CAS number626604-39-5
ATP CompetitiveY
FormOrange red solid
Hill FormulaC₁₈H₁₅N₅O₃
Chemical formulaC₁₈H₁₅N₅O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetGsk-3β
Primary Target K<sub>i</sub>25 nM against GSK-3β
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
361553-1MGCN 04055977214116

Documentation

GSK-3β Inhibitor XI - CAS 626604-39-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

GSK-3β Inhibitor XI - CAS 626604-39-5 - Calbiochem Certificates of Analysis

TitleLot Number
361553

References

Reference overview
Justman, Q.A., et al. 2009. Science 324, 509.
O'Neill, D.J., et al. 2004. Bioorg. Med. Chem. 12, 3167.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-April-2009 RFH
Synonyms3-(1-(3-Hydroxypropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-pyrazin-2-yl-pyrrole-2,5-dione, 7AIPM
DescriptionA cell-permeable, potent, specific, and ATP-competitive inhibitor of GSK-3β (Ki = 25 nM) that exhibits minimal inhibition against a panel of 79 commonly studied protein kinases, including several PKC isozymes. Shown to increase intracellular glycogen synthase activity in HEK293 cells (EC50 = 32 nM) and demonstrate metabolic stability in human liver microsomes (HLM; t1/2 >100 min).
FormOrange red solid
Intert gas (Yes/No) Packaged under inert gas
CAS number626604-39-5
Chemical formulaC₁₈H₁₅N₅O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesJustman, Q.A., et al. 2009. Science 324, 509.
O'Neill, D.J., et al. 2004. Bioorg. Med. Chem. 12, 3167.