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365251 Gö 6983 - CAS 133053-19-7 - Calbiochem

Gö 6983, CAS 133053-19-7, is a potent, cell-permeable, reversible, and ATP-competitive inhibitor of several PKC isozymes (IC50 = 7 nM for PKCα & β; 6 nM for PKCγ; 10 nM for PKCδ; & 60 nM for PKCζ).

Gö 6983 - CAS 133053-19-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-[1-(3-Dimethylaminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) maleimide, Go 6983

Primary Target: PKCα and PKCβ
365251
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
133053-19-7C₂₆H₂₆N₄O₃

Products

Catalogue NumberPackaging Qty/Pack
365251-500UGCN Plastic ampoule 500 μg
Description
OverviewA potent, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC) that inhibits several PKC isozymes (IC50 = 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ). Gö 6983 does not effectively inhibit PKCµ (IC50 = 20 µM) and can thus be used to differentiate PKCµ from other PKC isozymes.
Catalogue Number365251
Brand Family Calbiochem®
Synonyms2-[1-(3-Dimethylaminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) maleimide, Go 6983
References
ReferencesWang, D., et al. 1998. J. Biol. Chem. 273, 33027.
Stempka, L., et al. 1997. J. Biol. Chem. 272, 6805.
Gschwendt, M., et al. 1996. FEBS Lett. 392, 77.
Product Information
CAS number133053-19-7
ATP CompetitiveY
FormOrange red solid
Hill FormulaC₂₆H₂₆N₄O₃
Chemical formulaC₂₆H₂₆N₄O₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationGö 6983, CAS 133053-19-7, is a potent, cell-permeable, reversible, and ATP-competitive inhibitor of several PKC isozymes (IC50 = 7 nM for PKCα & β; 6 nM for PKCγ; 10 nM for PKCδ; & 60 nM for PKCζ).
Biological Information
Primary TargetPKCα and PKCβ
Primary Target IC<sub>50</sub>7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
365251-500UGCN 04055977192032

Documentation

Gö 6983 - CAS 133053-19-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Gö 6983 - CAS 133053-19-7 - Calbiochem Certificates of Analysis

TitleLot Number
365251

References

Reference overview
Wang, D., et al. 1998. J. Biol. Chem. 273, 33027.
Stempka, L., et al. 1997. J. Biol. Chem. 272, 6805.
Gschwendt, M., et al. 1996. FEBS Lett. 392, 77.

Citations

Title
  • Phuong Thi Nguyen Sarkis, et al. (2006) STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-α. Journal of Immunology 177, 4530-4540.
  • Ying Zhang, Mingjuan Liao and Maria L. Dufau. (2006) Phosphatidylinositol 3-kinase/protein kinase Cγ-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated depression of transcription of the luteinizing hormone receptor gene. Molecular and Cellular Biology 26, 6748-6761.
  • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.
  • Bai Luo, Stephen M. Prescott and Matthew K. Topham. (2003) Association of Diacylglycerol Kinase ζ with Protein Kinase C α: Spatial Regulation of Diacylglycerol Signaling. Journal of Cell Biology 160, 929-937.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision01-December-2015 JSW
    Synonyms2-[1-(3-Dimethylaminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) maleimide, Go 6983
    DescriptionA potent, cell-permeable, inhibitor of protein kinase C (PKC) that has been shown to selectively inhibit several PKC isozymes (IC50 = 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; 60 nM for PKCζ). Gö 6983 does not effectively inhibit PKCµ (IC50 = 20 µM) and can thus be used to differentiate PKCµ from other PKC isozymes.
    FormOrange red solid
    CAS number133053-19-7
    Chemical formulaC₂₆H₂₆N₄O₃
    Structure formulaStructure formula
    Purity≥98% by HPLC
    SolubilityDMSO (100 mg/ml)
    Storage Protect from light
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
    Toxicity Standard Handling
    ReferencesWang, D., et al. 1998. J. Biol. Chem. 273, 33027.
    Stempka, L., et al. 1997. J. Biol. Chem. 272, 6805.
    Gschwendt, M., et al. 1996. FEBS Lett. 392, 77.
    Citation
  • Phuong Thi Nguyen Sarkis, et al. (2006) STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-α. Journal of Immunology 177, 4530-4540.
  • Ying Zhang, Mingjuan Liao and Maria L. Dufau. (2006) Phosphatidylinositol 3-kinase/protein kinase Cγ-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated depression of transcription of the luteinizing hormone receptor gene. Molecular and Cellular Biology 26, 6748-6761.
  • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.
  • Bai Luo, Stephen M. Prescott and Matthew K. Topham. (2003) Association of Diacylglycerol Kinase ζ with Protein Kinase C α: Spatial Regulation of Diacylglycerol Signaling. Journal of Cell Biology 160, 929-937.
    		•