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344216 Formyl Peptide Receptor-Like 1 Agonist, WKYMVm - Calbiochem

The Formyl Peptide Receptor-Like 1 Agonist, WKYMVm controls the biological activity of Formyl Peptide Receptor-Like 1. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: FPRL1 Agonist, WKYMVm, H₂N-WKYMV-D-M-CONH₂

344216
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Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
344216-5MGCN Plastic ampoule 5 mg
Description
OverviewA potent chemoattractant that enhances leukocyte activity via activation of Formyl Peptide Receptor-Like 1 (FPRL1). Shown to activate phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells (EC50 = 510 pM). Also shown to stimulate inositol phosphate formation in U937 and HL60 cells, but has no effect on a variety of other cell lines (e.g. NIH3T3, PC12, Daudi, Sp2, Jurkat, H9, Molt-4, SupT-1, K562, and RBL-2H3). Stimulates phagocyte chemotaxis and [Ca2+] flux, and is more effective than fMLP (Cat. No. 05-22-2500) in generating superoxide in human neutrophils. Radioiodinatable at the tyrosine residue.
Catalogue Number344216
Brand Family Calbiochem®
SynonymsFPRL1 Agonist, WKYMVm, H₂N-WKYMV-D-M-CONH₂
References
ReferencesBae, Y.S., et al. 2004. J. Immunol. 173, 607.
Bae, Y.S., et al. 2003. Mol. Pharmacol. 64, 841.
Le, Y., et al. 1999. J. Immunol. 163, 6777.
Seo, J.K., et al. 1997. J. Immunol. 158, 1895.
Baek, S.H., et al. 1996. J. Biol. Chem. 271, 8170.
Product Information
ATP CompetitiveN
FormLyophilized
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₄₁H₆₁N₉O₇S₂
Chemical formulaC₄₁H₆₁N₉O₇S₂
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetFormyl Peptide Receptor-Like 1
Primary Target IC<sub>50</sub>EC50 = 510 pM in activating phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceH-Trp-Lys-Tyr-Met-Val-D-Met-CONH₂
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
344216-5MGCN 04055977215328

Documentation

Formyl Peptide Receptor-Like 1 Agonist, WKYMVm - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Formyl Peptide Receptor-Like 1 Agonist, WKYMVm - Calbiochem Certificates of Analysis

TitleLot Number
344216

References

Reference overview
Bae, Y.S., et al. 2004. J. Immunol. 173, 607.
Bae, Y.S., et al. 2003. Mol. Pharmacol. 64, 841.
Le, Y., et al. 1999. J. Immunol. 163, 6777.
Seo, J.K., et al. 1997. J. Immunol. 158, 1895.
Baek, S.H., et al. 1996. J. Biol. Chem. 271, 8170.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-June-2008 RFH
SynonymsFPRL1 Agonist, WKYMVm, H₂N-WKYMV-D-M-CONH₂
DescriptionA potent chemoattractant that enhances leukocyte activity via activation of Formyl Peptide Receptor-Like 1 (FPRL1). More poteut than fmlp at inducing neutrophil chemotaxis, neutrophil complement receptor 3. Shown to activate phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells (EC50 = 510 pM) and in U937 and HL60 cells. Has no effect inositide phosphate synthecs in a variety of other cell lines (e.g. NIH3T3, PC12, Daudi, Sp2, Jurkat, H9, Molt-4, SupT-1, K562, and RBL-2H3). Radioiodinatable at the tyrosine residue.
FormLyophilized
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₄₁H₆₁N₉O₇S₂
Peptide SequenceH-Trp-Lys-Tyr-Met-Val-D-Met-CONH₂
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBae, Y.S., et al. 2004. J. Immunol. 173, 607.
Bae, Y.S., et al. 2003. Mol. Pharmacol. 64, 841.
Le, Y., et al. 1999. J. Immunol. 163, 6777.
Seo, J.K., et al. 1997. J. Immunol. 158, 1895.
Baek, S.H., et al. 1996. J. Biol. Chem. 271, 8170.