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341610 FGF/PDGF/VEGF RTK Inhibitor - CAS 144335-37-5 - Calbiochem

The FGF/PDGF/VEGF RTK Inhibitor, also referenced under CAS 144335-37-5, controls the biological activity of FGF/PDGF/VEGF RTK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-Hydroxy-3-benzimidazol-2-ylhydroquinolin-2-one, PDGFR Tyrosine Kinase Inhibitor XVII, VEGFR Tyrosine Kinase Inhibitor XXX, VEGFR2 Kinase Inhibitor XXVIII

341610
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
144335-37-5C₁₆H₁₁N₃O₂

Products

Catalogue NumberPackaging Qty/Pack
341610-5MGCN Plastic ampoule 5 mg
Description
OverviewA cell-permeable benzimidazolo-hydroquinolinone compound that acts as a potent, reversible, ATP-competitive inhibitor against PDGFRβ, FGFR-1, and VEGFR-2 (IC50 = 20, 90, and 240 nM, respectively) and effectively suppresses VEGF-stimulated proliferation of HMVECs (EC50 = 420 nM).
Catalogue Number341610
Brand Family Calbiochem®
Synonyms4-Hydroxy-3-benzimidazol-2-ylhydroquinolin-2-one, PDGFR Tyrosine Kinase Inhibitor XVII, VEGFR Tyrosine Kinase Inhibitor XXX, VEGFR2 Kinase Inhibitor XXVIII
References
ReferencesRenhowe, P.A., et al. 2009. J. Med. Chem. 52, 278.
Product Information
CAS number144335-37-5
FormOff-white solid
Hill FormulaC₁₆H₁₁N₃O₂
Chemical formulaC₁₆H₁₁N₃O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
341610-5MGCN 04055977194869

Documentation

FGF/PDGF/VEGF RTK Inhibitor - CAS 144335-37-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

FGF/PDGF/VEGF RTK Inhibitor - CAS 144335-37-5 - Calbiochem Certificates of Analysis

TitleLot Number
341610

References

Reference overview
Renhowe, P.A., et al. 2009. J. Med. Chem. 52, 278.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-April-2011 RFH
Synonyms4-Hydroxy-3-benzimidazol-2-ylhydroquinolin-2-one, PDGFR Tyrosine Kinase Inhibitor XVII, VEGFR Tyrosine Kinase Inhibitor XXX, VEGFR2 Kinase Inhibitor XXVIII
DescriptionA cell-permeable benzimidazolo-hydroquinolinone compound that acts as a potent, reversible, ATP-competitive inhibitor against PDGFRβ, FGFR-1, and VEGFR-2 (IC50 = 20, 90, and 240 nM, respectively) and effectively suppresses VEGF-stimulated proliferation of HMVECs (EC50 = 420 nM).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number144335-37-5
Chemical formulaC₁₆H₁₁N₃O₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesRenhowe, P.A., et al. 2009. J. Med. Chem. 52, 278.