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14-939 ErbB2, active

ErbB2, active MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
14-939
10 µg  Also available in 250μg size as catalog # 14-939M and in bulk as catalog # 14-939-K.
Purchase on Sigma-Aldrich

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Overview

Replacement Information

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This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service.
Description
Catalogue Number14-939
Trade Name
  • Upstate
DescriptionErbB2, active
OverviewProtein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization
References
Product Information
PresentationProtein in 50mM Tris/HCl pH7.5, 150mM NaCl, 0.5mM EDTA, 0.01% CHAPS, 50% glycerol, 2mM DTT. Frozen solution.
Quality LevelMQ100
Applications
Key Applications
  • Kinase Assay
Biological Information
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Gene Symbol
  • ERBB2
  • HER2
  • NGL
  • NEU
  • HER-2
  • TKR1
  • MLN19
Protein TargetErbB2
Purification MethodPurified using immobilized metal affinity chromatography.
Target Sub-FamilyTK
UniProt Number
Molecular Weight69 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by phosphorylation of poly(Glu, Tyr) (4:1)
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C
Packaging Information
Material Size10 µg
Material PackageAlso available in 250μg size as catalog # 14-939M and in bulk as catalog # 14-939-K.
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
14-939 04053252960864