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324890 E-64 Protease Inhibitor - CAS 66701-25-5 - Calbiochem

E-64 Protease Inhibitor, CAS 66701-25-5, is an irreversible inhibitor of cysteine proteases. Interacts with the Sn subsites of proteases. Has no action on cysteine residues in other proteins.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (2R,3R)-3-((S)-1-(4-Guanidinobutylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)oxirane-2-carboxylic acid, trans-Epoxysuccinyl-L-​leucylamido(4-​guanidino)​butane, L-trans-​3-​Carboxyoxiran-​2-​carbonyl-L-leucylagmatine, N-​(trans-​Epoxysuccinyl)​-L-leucine 4-​guanidinobutylamide

Primary Target: cysteine proteases
324890
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
66701-25-5C₁₅H₂₇N₅O₅

Products

Catalogue NumberPackaging Qty/Pack
324890-1MGCN Plastic ampoule 1 mg
324890-25MGCN Glass bottle 25 mg
324890-5MGCN Plastic ampoule 5 mg
Description
OverviewIrreversible inhibitor of cysteine proteases. Interacts with the Sn subsites of proteases. Has no action on cysteine residues in other proteins. Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Specific active site titrant.
Catalogue Number324890
Brand Family Calbiochem®
Synonyms(2R,3R)-3-((S)-1-(4-Guanidinobutylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)oxirane-2-carboxylic acid, trans-Epoxysuccinyl-L-​leucylamido(4-​guanidino)​butane, L-trans-​3-​Carboxyoxiran-​2-​carbonyl-L-leucylagmatine, N-​(trans-​Epoxysuccinyl)​-L-leucine 4-​guanidinobutylamide
References
ReferencesMatsumoto, K., et al. 1999. Biopolymers 51, 99.
Sarin, A., et al. 1994. J. Immunol. 153, 862.
Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
Barrett, A.J. 1982. Biochem. J. 201, 189.
Product Information
CAS number66701-25-5
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₅H₂₇N₅O₅
Chemical formulaC₁₅H₂₇N₅O₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
ApplicationE-64 Protease Inhibitor, CAS 66701-25-5, is an irreversible inhibitor of cysteine proteases. Interacts with the Sn subsites of proteases. Has no action on cysteine residues in other proteins.
Biological Information
Primary Targetcysteine proteases
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSRR0390000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
324890-1MGCN 04055977196146
324890-25MGCN 04055977196160
324890-5MGCN 04055977196177

Documentation

E-64 Protease Inhibitor - CAS 66701-25-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

E-64 Protease Inhibitor - CAS 66701-25-5 - Calbiochem Certificates of Analysis

TitleLot Number
324890

References

Reference overview
Matsumoto, K., et al. 1999. Biopolymers 51, 99.
Sarin, A., et al. 1994. J. Immunol. 153, 862.
Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
Barrett, A.J. 1982. Biochem. J. 201, 189.

Citations

Title
  • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision12-July-2013 JSW
    Synonyms(2R,3R)-3-((S)-1-(4-Guanidinobutylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)oxirane-2-carboxylic acid, trans-Epoxysuccinyl-L-​leucylamido(4-​guanidino)​butane, L-trans-​3-​Carboxyoxiran-​2-​carbonyl-L-leucylagmatine, N-​(trans-​Epoxysuccinyl)​-L-leucine 4-​guanidinobutylamide
    DescriptionIrreversible inhibitor of cysteine proteases. Has no action on cysteine residues in other proteins. Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Specific active site titrant.
    FormWhite solid
    CAS number66701-25-5
    RTECSRR0390000
    Chemical formulaC₁₅H₂₇N₅O₅
    Structure formulaStructure formula
    Purity≥98% by HPLC
    SolubilityDMSO (25 mg/ml) or H₂O (20 mg/ml)
    Storage -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
    Toxicity Standard Handling
    ReferencesMatsumoto, K., et al. 1999. Biopolymers 51, 99.
    Sarin, A., et al. 1994. J. Immunol. 153, 862.
    Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
    Barrett, A.J. 1982. Biochem. J. 201, 189.
    Citation
  • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
    		•