217699 Sigma-AldrichCdk1 Inhibitor IV, RO-3306 - Calbiochem
RO-3306 is a cell-permeable, potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively).
More>> RO-3306 is a cell-permeable, potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively). Less<<Cdk1 Inhibitor IV, RO-3306 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Overview
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Key Spec Table
| Empirical Formula |
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| C₁₈H₁₃N₃OS₂ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 217699-5MGCN | Glass bottle | 5 mg |
| Description | |
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| Overview | A cell-permeable quinolinyl thiazolinone compound that acts as a potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively). It affects Cdk2/E, PKCδ, and SGK only at much higher concentrations (Ki = 340, 318, and 497 nM, respectively), and shows little effect against Cdk4/D and six other commonly studied kinases (Ki ≥ 2 µM). Short-term treatment for up to 20 hrs results in fully reversible G2/M cell cycle arrest, while prolonged treament (>48 hrs) results in apoptotic cell death in proliferating cancer cells, but not in nontumorigenic epithelial cell lines. Also available as a 10 mM solution in DMSO (Cat. No. 217721). |
| Catalogue Number | 217699 |
| Brand Family | Calbiochem® |
| References | |
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| References | Vassilev, L.T., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 10660. |
| Product Information | |
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| ATP Competitive | Y |
| Form | Brown solid |
| Hill Formula | C₁₈H₁₃N₃OS₂ |
| Chemical formula | C₁₈H₁₃N₃OS₂ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | Cdk1 |
| Primary Target K<sub>i</sub> | 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 217699-5MGCN | 04055977202342 |
Documentation
Cdk1 Inhibitor IV, RO-3306 - Calbiochem SDS
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Cdk1 Inhibitor IV, RO-3306 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 217699 |
References
| Reference overview |
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| Vassilev, L.T., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 10660. |