Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

219502 Cathepsin L Inhibitor, CAA0225 - Calbiochem

Cathepsin L Inhibitor, CAA0225 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
219502
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₈H₂₉N₃O₅

Products

Catalogue NumberPackaging Qty/Pack
219502-1MGCN 1 mg
Description
OverviewAn epoxysuccinyl peptide highly selective for rat liver cathepsin L (IC50 = 1.9 nM), while exhibiting little to no effect on rat liver cathepsin B at concentrations higher than 1000-5000 nM, in vitro. During autophagy, it has been shown through immunoblotting that CAA0225 (10 µg/ml) effectively inhibits the degradation of LC3-II and GABARAP compared to control, in nutrient-deprived HeLa and Huh-7 cells.
Catalogue Number219502
Brand Family Calbiochem®
References
ReferencesTakahashi, K., et al. 2009. Biol. Pharm. Bull. 32, 475.
Ueno, T., et al. 2009. Autophagy 5, 878.
Product Information
FormWhite solid
Hill FormulaC₂₈H₂₉N₃O₅
Chemical formulaC₂₈H₂₉N₃O₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥ 95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
219502-1MGCN 04055977218039

Documentation

Cathepsin L Inhibitor, CAA0225 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Cathepsin L Inhibitor, CAA0225 - Calbiochem Certificates of Analysis

TitleLot Number
219502

References

Reference overview
Takahashi, K., et al. 2009. Biol. Pharm. Bull. 32, 475.
Ueno, T., et al. 2009. Autophagy 5, 878.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-March-2011 RFH
DescriptionAn epoxysuccinyl peptide highly selective for rat liver cathepsin L (IC50 = 1.9 nM), while exhibiting little to no effect on rat liver cathepsin B at concentrations higher than 1000-5000 nM, in vitro. During autophagy, it has been shown through immunoblotting that CAA0225 (10 µg/ml) effectively inhibits the degradation of LC3-II and GABARAP compared to control, in nutrient-deprived HeLa and Huh-7 cells.
FormWhite solid
Chemical formulaC₂₈H₂₉N₃O₅
Structure formulaStructure formula
Purity≥ 95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesTakahashi, K., et al. 2009. Biol. Pharm. Bull. 32, 475.
Ueno, T., et al. 2009. Autophagy 5, 878.