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218773 Caspase-8 Inhibitor I, Cell-Permeable - Calbiochem

Caspase-8 Inhibitor I, Cell-Permeable, is a potent, reversible inhibitor of caspase-8 and Granzyme B.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Granzyme B Inhibitor II, Cell-permeable, IETD-CHO, Cell-permeable

Primary Target: caspase-8
218773
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₉₅H₁₆₂N₂₀O₂₆

Products

Catalogue NumberPackaging Qty/Pack
218773-1MGCN Plastic ampoule 1 mg
Description
OverviewA potent, cell-permeable, and reversible inhibitor of caspase-8 and Granzyme B. The N-terminal sequence (amino acids 1-16) corresponds to the hydrophobic region of the signal peptide of Kaposi fibroblast growth factor and confers cell permeability to the peptide.
Catalogue Number218773
Brand Family Calbiochem®
SynonymsGranzyme B Inhibitor II, Cell-permeable, IETD-CHO, Cell-permeable
References
ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Hamada, E., et al. 1990. J. Hepatol. 30, 807.
Product Information
ATP CompetitiveN
FormWhite lyophilized solid
Hill FormulaC₉₅H₁₆₂N₂₀O₂₆
Chemical formulaC₉₅H₁₆₂N₂₀O₂₆
ReversibleY
Quality LevelMQ100
Applications
ApplicationCaspase-8 Inhibitor I, Cell-Permeable, is a potent, reversible inhibitor of caspase-8 and Granzyme B.
Biological Information
Primary Targetcaspase-8
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-CHO
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
218773-1MGCN 04055977218725

Documentation

Caspase-8 Inhibitor I, Cell-Permeable - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Caspase-8 Inhibitor I, Cell-Permeable - Calbiochem Certificates of Analysis

TitleLot Number
218773

References

Reference overview
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Hamada, E., et al. 1990. J. Hepatol. 30, 807.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-June-2008 RFH
SynonymsGranzyme B Inhibitor II, Cell-permeable, IETD-CHO, Cell-permeable
DescriptionPotent, cell-permeable and reversible inhibitor of caspase-8 and Granzyme B.
FormWhite lyophilized solid
Chemical formulaC₉₅H₁₆₂N₂₀O₂₆
Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-CHO
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Hamada, E., et al. 1990. J. Hepatol. 30, 807.