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217386 Carboxy-PTIO, Sodium Salt - Calbiochem

Reacts with nitric oxide at pH 7.4, resulting in the generation of NO2⁻/NO3⁻ with a rate constant of 1 x 10⁴ M⁻¹sec⁻¹.

Carboxy-PTIO, Sodium Salt - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, Na

217386
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₄H₁₆N₂O₄ · Na

Products

Catalogue NumberPackaging Qty/Pack
217386-10MGCN Plastic ampoule 10 mg
Description
OverviewReacts with nitric oxide at pH 7.4, resulting in the generation of NO2-/NO3- with a rate constant of 1 x 104 M-1sec-1. Prevents SIN-1 induced endothelial cell death. Has potent therapeutic value in endotoxin shock through its nitric oxide scavenging action.
Catalogue Number217386
Brand Family Calbiochem®
Synonyms2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, Na
References
ReferencesIshii, M., et al., 1999. J. Cardiovasc. Pharmacol. 33, 295.
Amano, F., and Nova, J. 1995. FEBS Lett. 368, 425.
Hogg, N., et al. 1995. Free Radical Res. 22, 47.
Az-ma, T., et al. 1994. Life Sci. 54, 185.
Yoshida, M., et al. 1994. Biochem. Biophys. Res. Commun. 202, 923.
Akaike, T., et al. 1993. Biochemistry 32, 827.
Yoshida, K., et al. 1993. Infect. Immun. 61, 3552.
Product Information
ATP CompetitiveN
FormDark blue solid
Hill FormulaC₁₄H₁₆N₂O₄ · Na
Chemical formulaC₁₄H₁₆N₂O₄ · Na
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetNitric oxide scavenging action
Purity≥97% by TLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Aqueous stock solutions are stable for up to 1 week at 4°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
217386-10MGCN 04055977219357

Documentation

Carboxy-PTIO, Sodium Salt - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Carboxy-PTIO, Sodium Salt - Calbiochem Certificates of Analysis

TitleLot Number
217386

References

Reference overview
Ishii, M., et al., 1999. J. Cardiovasc. Pharmacol. 33, 295.
Amano, F., and Nova, J. 1995. FEBS Lett. 368, 425.
Hogg, N., et al. 1995. Free Radical Res. 22, 47.
Az-ma, T., et al. 1994. Life Sci. 54, 185.
Yoshida, M., et al. 1994. Biochem. Biophys. Res. Commun. 202, 923.
Akaike, T., et al. 1993. Biochemistry 32, 827.
Yoshida, K., et al. 1993. Infect. Immun. 61, 3552.

Brochure

Title
Pathways and Biomarkers of Oxidative Stress
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-June-2008 RFH
Synonyms2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, Na
DescriptionReacts with nitric oxide at pH 7.4, resulting in the generation of NO2-/NO3- with a rate constant of 1 x 104 M-1sec-1. Prevents SIN-1 induced endothelial cell death. Reported to have potent therapeutic value in endotoxin shock through its nitric oxide scavenging action.
FormDark blue solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₄H₁₆N₂O₄ · Na
Structure formulaStructure formula
Purity≥97% by TLC
SolubilityHEPES Buffer (0.4 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Aqueous stock solutions are stable for up to 1 week at 4°C.
Toxicity Standard Handling
ReferencesIshii, M., et al., 1999. J. Cardiovasc. Pharmacol. 33, 295.
Amano, F., and Nova, J. 1995. FEBS Lett. 368, 425.
Hogg, N., et al. 1995. Free Radical Res. 22, 47.
Az-ma, T., et al. 1994. Life Sci. 54, 185.
Yoshida, M., et al. 1994. Biochem. Biophys. Res. Commun. 202, 923.
Akaike, T., et al. 1993. Biochemistry 32, 827.
Yoshida, K., et al. 1993. Infect. Immun. 61, 3552.