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233100 CL-387,785 - CAS 194423-06-8 - Calbiochem

A cell-permeable and irreversible inhibitor of EGF-receptor (EGFR) kinase activity in vivo (IC₅₀ = 250-490 pM) as well as EGF-stimulated autophosphorylation of tyrosine residues in the EGFR in vivo (IC₅₀ = 5 nM).

CL-387,785 - CAS 194423-06-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide, EKI-785

Primary Target: EGFR kinase activity
233100
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
194423-06-8C₁₈H₁₃BrN₄O

Products

Catalogue NumberPackaging Qty/Pack
233100-1MGCN Plastic ampoule 1 mg
Description
OverviewA cell-permeable and irreversible inhibitor of EGF-receptor (EGFR) kinase activity in vivo (IC50 = 250-490 pM) as well as EGF-stimulated autophosphorylation of tyrosine residues in the EGFR in vivo (IC50 = 5 nM). Blocks EGF-mediated growth in A431 cells. Inhibits proliferation of EGFR or c-ErbB2 expressing cells (IC50 = 31-125 nM) by covalently binding to the EGFR.
Catalogue Number233100
Brand Family Calbiochem®
SynonymsN-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide, EKI-785
References
ReferencesSweeney, W.E., et al. 2000. Kidney Int. 57, 33.
Discafani, C.M., et al. 1999. Biochem. Pharmacol. 57, 917.
Sweeney, W.E., et. al. 1999. Kidney Int. 56, 406.
Product Information
CAS number194423-06-8
ATP CompetitiveN
FormPale yellow solid
Hill FormulaC₁₈H₁₃BrN₄O
Chemical formulaC₁₈H₁₃BrN₄O
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetEGFR kinase activity
Primary Target IC<sub>50</sub>250-490 pM inhibiting EGF-receptor (EGFR) kinase activity in vivo; 5 nM inhibiting EGF-stimulated autophosphorylation of tyrosine residues in the EGFR in vivo
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
233100-1MGCN 04055977217612

Documentation

CL-387,785 - CAS 194423-06-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

CL-387,785 - CAS 194423-06-8 - Calbiochem Certificates of Analysis

TitleLot Number
233100

References

Reference overview
Sweeney, W.E., et al. 2000. Kidney Int. 57, 33.
Discafani, C.M., et al. 1999. Biochem. Pharmacol. 57, 917.
Sweeney, W.E., et. al. 1999. Kidney Int. 56, 406.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-April-2011 RFH
SynonymsN-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide, EKI-785
DescriptionA cell-permeable and irreversible inhibitor of EGF-stimulated autophosphorylation of tyrosine residues in the epidermal growth factor receptor (EGFR) in vivo (IC50 = 250-490 pM) and blocks EGF-mediated growth. Also inhibits proliferation of cells that overexpress EGFR or c-Erb-2 (IC50 = 31-125 nM) by covalently binding to EGFR.
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number194423-06-8
Chemical formulaC₁₈H₁₃BrN₄O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (200 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesSweeney, W.E., et al. 2000. Kidney Int. 57, 33.
Discafani, C.M., et al. 1999. Biochem. Pharmacol. 57, 917.
Sweeney, W.E., et. al. 1999. Kidney Int. 56, 406.