219506 Sigma-AldrichCBFβ-Runx1 Inhibitor II, Ro5-3335 - CAS 30195-30-3 - Calbiochem
The CBFβ-Runx1 Inhibitor II, Ro5-3335, also referenced under CAS 30195-30-3, suppresses CBFα/Runx1-CBFβ transactivation activity (25 µM; 293-0 cells) via direct bindings to both subunits of the heterodimeric transcription factor complex.
More>> The CBFβ-Runx1 Inhibitor II, Ro5-3335, also referenced under CAS 30195-30-3, suppresses CBFα/Runx1-CBFβ transactivation activity (25 µM; 293-0 cells) via direct bindings to both subunits of the heterodimeric transcription factor complex. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Ro53335, CBFα-CBFβ Inhibitor II, [7-chloro-5-(2-pyrryl)-3H-1,4 benzodiazapin-2-(H)-one]
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Overview
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Products
| Catalogue Number | Packaging | Qty/Pack | |
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| 219506-10MGCN | Glass bottle | 10 mg |
| Description | |
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| Overview | A cell-permeable benzodiazepine that suppresses CBFα/Runx1-CBFβ transactivation activity (25 µM; 293-0 cells) via direct bindings to both subunits of the heterodimeric transcription factor complex. Shown to inhibit oncogenic fusion CBFB-MYH11-, TEL-RUNX1-, and RUNX1-ETO-, dependent leukemia cells proliferation (IC50 = 1.1 to 21.7 µM) in vitro and more effectively reduce peripheral blood c-kit+ population (300 mg/kg/d via animal feed) than Cytarabine (Cat. No. 251010) in a murine Cbfb-MYH11 leukemia model in vivo. Comparing to CBFβ-Runx1 Inhibitor I (Cat. No. 219505), Ro5-3335 modulates the Runx1-CBFβ heterodimer formation without completely disrupting the subunits interaction. |
| Catalogue Number | 219506 |
| Brand Family | Calbiochem® |
| Synonyms | Ro53335, CBFα-CBFβ Inhibitor II, [7-chloro-5-(2-pyrryl)-3H-1,4 benzodiazapin-2-(H)-one] |
| References | |
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| References | Cunningham, L, et al. 2012. Proc Natl Acad Sci USA. 109, 14594. Witvrouw, M., et al. 1992. Antimicrob Agents Chemother. 36, 2628. |
| Product Information | |
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| CAS number | 30195-30-3 |
| Form | Off-white solid |
| Hill Formula | C₁₃H₁₀ClN₃O |
| Chemical formula | C₁₃H₁₀ClN₃O |
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| Quality Level | MQ100 |
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| Primary Target IC<sub>50</sub> | 0.5 µM |
| Purity | ≥98% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 219506-10MGCN | 04055977218084 |
Documentation
CBFβ-Runx1 Inhibitor II, Ro5-3335 - CAS 30195-30-3 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 219506 |
References
| Reference overview |
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| Cunningham, L, et al. 2012. Proc Natl Acad Sci USA. 109, 14594. Witvrouw, M., et al. 1992. Antimicrob Agents Chemother. 36, 2628. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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