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200499 Bexarotene - CAS 153559-49-0 - Calbiochem

200499
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Overview

Key Spec Table

CAS #Empirical Formula
153559-49-0C₂₄H₂₈O₂

Products

Catalogue NumberPackaging Qty/Pack
200499-50MGCN Glass bottle 50 mg
Description
OverviewA retinoid X receptor (RXR) agonist that can permeate the blood-brain barrier and rapidly reduce Aβ40 and Aβ42 levels in APP/PS1 mice in an ApoE-dependent manner (25% reduction in 6 h and 50% reduction in 72 h). Causes a rapid reversal of cognitive, social, and olfactory deficts. Shown to progressively enhance the expression of ApoE and ATP-binding cassette transporters ABCA1 and ABCG1. Also stimulates the secretion of highly lapidated HDL particles in primary microglia and astrocytes. Does not affect the levels of Aβ proteases, insulin degrading enzyme, and neprilysin.
Catalogue Number200499
Brand Family Calbiochem®
Synonyms4-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid
References
ReferencesCramer, P.E., et al. 2012. Science Exp. 335, 1503.
Product Information
CAS number153559-49-0
FormWhite to pale yellow powder
Hill FormulaC₂₄H₂₈O₂
Chemical formulaC₂₄H₂₈O₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Regulatory Review
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
200499-50MGCN 04055977221558