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196419 BAPTA/AM - CAS 126150-97-8 - Calbiochem

BAPTA/AM - CAS 126150-97-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1,2-bis(o-Aminophenoxy)ethane-N,N,Nʹ,Nʹ-tetraacetic Acid Tetra(acetoxymethyl) Ester

196419
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
126150-97-8C₃₄H₄₀N₂O₁₈

Products

Catalogue NumberPackaging Qty/Pack
196419-25MGCN Plastic ampoule 25 mg
Description
OverviewMembrane-permeable form of BAPTA. Can be loaded into a wide variety of cells, where it is hydrolyzed by cytosolic esterases and is trapped intracellularly as the active chelator BAPTA. Prevents cocaine-induced ventricular fibrillations. Abolishes vitamin D3-induced increase in intracellular Ca2+. Induces inactivation of protein kinase C. Also inhibits thapsigargin-induced apoptosis in rat thymocytes.
Catalogue Number196419
Brand Family Calbiochem®
Synonyms1,2-bis(o-Aminophenoxy)ethane-N,N,Nʹ,Nʹ-tetraacetic Acid Tetra(acetoxymethyl) Ester
References
ReferencesBissonnette, M., et al. 1994. Am. J. Physiol. 267, G465.
Jiang, S., et al. 1994. Exp. Cell Res. 212, 84.
Billman, G.E. 1993. Am. J. Physiol. 265, H1529.
Dieter, P., et al. 1993. Biol. Chem. Hoppe Seyler 374, 171.
Harrison, S.M., and Bers, D.M. 1987. Biochim. Biophys. Acta 925, 133.
Harrison, S.M., and Bers, D.M. 1987. J. Biophys. 51, 102A.
Marban, E., et al. 1986. J. Clin. Invest. 78, 1185.
Tsien, R.Y. 1981. Nature 290, 527.
Tsien, R.Y. 1980. Biochemistry 19, 2396.
Product Information
CAS number126150-97-8
FormLight yellow solid
Hill FormulaC₃₄H₄₀N₂O₁₈
Chemical formulaC₃₄H₄₀N₂O₁₈
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥90% by TLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot, purge with inert gas and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
196419-25MGCN 04055977206494

Documentation

BAPTA/AM - CAS 126150-97-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

BAPTA/AM - CAS 126150-97-8 - Calbiochem Certificates of Analysis

TitleLot Number
196419

References

Reference overview
Bissonnette, M., et al. 1994. Am. J. Physiol. 267, G465.
Jiang, S., et al. 1994. Exp. Cell Res. 212, 84.
Billman, G.E. 1993. Am. J. Physiol. 265, H1529.
Dieter, P., et al. 1993. Biol. Chem. Hoppe Seyler 374, 171.
Harrison, S.M., and Bers, D.M. 1987. Biochim. Biophys. Acta 925, 133.
Harrison, S.M., and Bers, D.M. 1987. J. Biophys. 51, 102A.
Marban, E., et al. 1986. J. Clin. Invest. 78, 1185.
Tsien, R.Y. 1981. Nature 290, 527.
Tsien, R.Y. 1980. Biochemistry 19, 2396.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure

Citations

Title
  • Meenalakshmi M. Mariappan, et al. (2005) Phospholipase Cγ-Erk Axis in Vascular Endothelial Growth Factor-Induced Eukaryotic Initiation Factor 4E Phosphorylation and Protein Synthesis in Renal Epithelial Cells. Journal of Biological Chemistry 280, 28402-28411.
  • Martha E. O'Donnnell, et al. (2005) Arginine Vasopressin Stimulation of Cerebral Microvascular Endothelial Cell Na-K-Cl Cotransporter Activity is V1 Receptor and [Ca] Dependent. American Journal of Physiology Cell Physiology 289, C283-C292.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision17-April-2008 RFH
    Synonyms1,2-bis(o-Aminophenoxy)ethane-N,N,Nʹ,Nʹ-tetraacetic Acid Tetra(acetoxymethyl) Ester
    DescriptionMembrane-permeable form of BAPTA. Can be loaded into a wide variety of cells, where it is hydrolyzed by cytosolic esterases and is trapped intracellularly as the active chelator BAPTA. Prevents cocaine-induced ventricular fibrillations. Induces inactivation of protein kinase C. Also inhibits thapsigargin-induced apoptosis in rat thymocytes.
    FormLight yellow solid
    Intert gas (Yes/No) Packaged under inert gas
    CAS number126150-97-8
    Chemical formulaC₃₄H₄₀N₂O₁₈
    Structure formulaStructure formula
    Purity≥90% by TLC
    SolubilityDMSO (10 mg/ml)
    Storage Protect from light
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot, purge with inert gas and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
    Toxicity Irritant
    ReferencesBissonnette, M., et al. 1994. Am. J. Physiol. 267, G465.
    Jiang, S., et al. 1994. Exp. Cell Res. 212, 84.
    Billman, G.E. 1993. Am. J. Physiol. 265, H1529.
    Dieter, P., et al. 1993. Biol. Chem. Hoppe Seyler 374, 171.
    Harrison, S.M., and Bers, D.M. 1987. Biochim. Biophys. Acta 925, 133.
    Harrison, S.M., and Bers, D.M. 1987. J. Biophys. 51, 102A.
    Marban, E., et al. 1986. J. Clin. Invest. 78, 1185.
    Tsien, R.Y. 1981. Nature 290, 527.
    Tsien, R.Y. 1980. Biochemistry 19, 2396.
    Citation
  • Meenalakshmi M. Mariappan, et al. (2005) Phospholipase Cγ-Erk Axis in Vascular Endothelial Growth Factor-Induced Eukaryotic Initiation Factor 4E Phosphorylation and Protein Synthesis in Renal Epithelial Cells. Journal of Biological Chemistry 280, 28402-28411.
  • Martha E. O'Donnnell, et al. (2005) Arginine Vasopressin Stimulation of Cerebral Microvascular Endothelial Cell Na-K-Cl Cotransporter Activity is V1 Receptor and [Ca] Dependent. American Journal of Physiology Cell Physiology 289, C283-C292.
    		•