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189510 Autotaxin Inhibitor I, S32826 - CAS 1103672-43-0 - Calbiochem

The Autotaxin Inhibitor I, S32826, also referenced under CAS 1103672-43-0, controls the biological activity of Autotaxin.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ATX Inhibitor I, (4-(Tetradecanoylamino)benzyl)phosphonic acid disodium, dihydrate

189510
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1103672-43-0C₂₁H₃₄NO₄PNa₂ • 2H₂O

Products

Catalogue NumberPackaging Qty/Pack
189510-5MGCN Glass bottle 5 mg
Description
OverviewA phosphonate compound that potently inhibits both the phosphodiesterase (IC50 = 9 nM in pNppp assay using ATX β) and the lysoPLD (IC50 = 5.6 nM and 47 nM, by enzyme-linked fluorescence detection or autoradiography by TLC, respectively, using ATX β) activities of ATX α/β/γ, while exhibiting much reduced (IC50 ~ 6 µM and 15 µM against Src and PTP-1B, respectively) or little activity toward 29 other receptors and enzymes. Shown to block LPA release from murine 3T3F422A adipocytes (IC50 = 90 nM) in vitro and from excised human and rat adipose tissues (by ~70% inhibition at 0.2 and 1 µM, respectively) in cultures ex vivo. The in vivo applicability of S32826 is limited by its low epithelial permeability and other poor pharmacokinetic properties. CTAB (Cat. No. 219374) is reported to counteract the inhibitory activity of S32826, 2-methyl-2,4-pentanediol can be used instead to stabilize purified enzyme in solution during S32826 inhibition assays.
Catalogue Number189510
Brand Family Calbiochem®
SynonymsATX Inhibitor I, (4-(Tetradecanoylamino)benzyl)phosphonic acid disodium, dihydrate
References
ReferencesBoutin, J.A., and Ferry, G. 2009. Cell Mol. Life Sci. 66, 3009.
Samadi, N., et al. 2009. Oncogene 28, 1028.
Ferry, G., et al. 2008. J. Pharm. Exp. Ther. 327, 809.
Product Information
CAS number1103672-43-0
FormWhite powder
Hill FormulaC₂₁H₃₄NO₄PNa₂ • 2H₂O
Chemical formulaC₂₁H₃₄NO₄PNa₂ • 2H₂O
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Regulatory Review
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
189510-5MGCN 04055977221862

Documentation

Autotaxin Inhibitor I, S32826 - CAS 1103672-43-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Autotaxin Inhibitor I, S32826 - CAS 1103672-43-0 - Calbiochem Certificates of Analysis

TitleLot Number
189510

References

Reference overview
Boutin, J.A., and Ferry, G. 2009. Cell Mol. Life Sci. 66, 3009.
Samadi, N., et al. 2009. Oncogene 28, 1028.
Ferry, G., et al. 2008. J. Pharm. Exp. Ther. 327, 809.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-March-2011 RFH
SynonymsATX Inhibitor I, (4-(Tetradecanoylamino)benzyl)phosphonic acid disodium, dihydrate
DescriptionA phosphonate compound that potently inhibits both the phosphodiesterase (IC50 = 9 nM in pNppp assay using ATX β) and the lysoPLD (IC50 = 5.6 nM and 47 nM, by enzyme-linked fluorescence detection or autoradiography by TLC, respectively, using ATX β) activities of ATX α/β/γ, while exhibiting much reduced (IC50 ~6 µM and 15 µM against Src and PTP-1B, respectively) or little activity toward 29 other receptors and enzymes. Shown to block LPA release from murine 3T3F422A adipocytes (IC50 = 90 nM) in vitro and from excised human and rat adipose tissues (by ~70% inhibition at 0.2 and 1 µM, respectively) in cultures ex vivo. The in vivo applicability of S32826 is limited by its low epithelial permeability and other poor pharmacokinetic properties. CTAB (Cat. No. 219374) is reported to counteract the inhibitory activity of S32826, 2-methyl-2,4-pentanediol can be used instead to stabilize purified enzyme in solution during S32826 inhibition assays.
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
CAS number1103672-43-0
Chemical formulaC₂₁H₃₄NO₄PNa₂ • 2H₂O
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityH₂O (0.5 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Regulatory Review
ReferencesBoutin, J.A., and Ferry, G. 2009. Cell Mol. Life Sci. 66, 3009.
Samadi, N., et al. 2009. Oncogene 28, 1028.
Ferry, G., et al. 2008. J. Pharm. Exp. Ther. 327, 809.