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06-1115 Anti-Interleukin-18 (IL-18) Antibody

This Anti-Interleukin-18 (IL-18) Antibody is validated for use in WB, IH(P) for the detection of Interleukin-18 (IL-18).

Anti-Interleukin-18 (IL-18) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Cytokines & Cytokine Receptors Gene Symbol: IL-18, IL18, IGIF, IL-18, IL1F4, IL-1g UniProt Number: Q14116
06-1115
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, Chp, Rhesus Macaque, PmWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
Description
Catalogue Number06-1115
DescriptionAnti-Interleukin-18 (IL-18) Antibody
Alternate Names
  • interleukin 18 (interferon-gamma-inducing factor)
  • IL-1 gamma
  • IFN-gamma-inducing factor
  • iboctadekin
  • interleukin-18
  • Interleukin-1 gamma
  • Iboctadekin
  • Interferon gamma-inducing factor
Background InformationIL-18 has been shown to be a pro-inflammatory cytokine that induces interferon-gamma. IL-18 has also been found to have the ability to activate nuclear factor-kappaB (NFkB), express Fas ligand, induce CC and CXC chemokines, and also has been found to increase the production of viable human immunodeficiency virus. IL-18 has been linked to syndromes displaying symptoms of chronic low-levels of inflammation. IL-18 also seems to have some control over homeostasis and behavior in the central nervous system as well as neuroinflammatory activity.
References
Product Information
FormatAffinity Purified
Control
  • Human tonsil tissue lysate
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-Interleukin-18 (IL-18) Antibody is validated for use in WB, IH(P) for the detection of Interleukin-18 (IL-18).
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application NotesWestern Blot (Snap i.d.) Analysis: 5 µg/mL from a previous lot detected IL-18 in 10 µg of human tonsil tissue lysate.

Immunohistochemistry Analysis: A 1:600 dilution from a previous lot detected IL-18 in normal human spleen tissue.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human Interleukin-18.
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
Species Reactivity
  • Human
  • Chimpanzee
  • Rhesus Macaque
  • Primate
Species Reactivity NoteDemonstrated to react with human.
Predicted to react with chimpanzee, rhesus macaque, and primate based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThe protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. [provided by RefSeq].
Gene Symbol
  • IL-18
  • IL18
  • IGIF
  • IL-18
  • IL1F4
  • IL-1g
Purification MethodAffinity Purfied
UniProt Number
UniProt SummaryFUNCTION: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.

SUBCELLULAR LOCATION: Secreted.

SEQUENCE SIMILARITIES: Belongs to the IL-1 family.
Molecular Weight~22 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in human tonsil tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected IL-18 in 10 µg of human tonsil tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
06-1115 04053252377525

Documentation

Anti-Interleukin-18 (IL-18) Antibody SDS

Title

Safety Data Sheet (SDS) 

Anti-Interleukin-18 (IL-18) Antibody Certificates of Analysis

TitleLot Number
Anti-Interleukin-18 (IL-18) - 2468168 2468168
Anti-Interleukin-18 (IL-18) - 1995608 1995608
Anti-Interleukin-18 (IL-18) - 2273979 2273979
Anti-Interleukin-18 (IL-18) - 2512109 2512109
Anti-Interleukin-18 (IL-18) - 3426772 3426772
Anti-Interleukin-18 (IL-18) - 3506599 3506599
Anti-Interleukin-18 (IL-18) - 3738075 3738075
Anti-Interleukin-18 (IL-18) - 4030990 4030990
Anti-Interleukin-18 (IL-18) - 4047601 4047601
Anti-Interleukin-18 (IL-18) - NRG1821355 NRG1821355
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Brochure

Title
Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling