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06-890 Anti-HDAC3 Antibody

06-890
200 µg  
Purchase on Sigma-Aldrich

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Overview

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, RWBRbPurifiedPolyclonal Antibody
Description
Catalogue Number06-890
Brand Family Upstate
Trade Name
  • Upstate
DescriptionAnti-HDAC3 Antibody
Product Information
FormatPurified
Presentationof 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Quality LevelMQ100
Applications
ApplicationAnti-HDAC3 Antibody is a Rabbit Polyclonal Antibody for detection of HDAC3 also known as histone deacetylase 3 & has been tested in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogenpeptide corresponding to amino acids 411-428 of human HDAC3 (NEFYDGDHDNDKESDVEI)
HostRabbit
SpecificityHDAC3
IsotypeIgG
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryHistones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
Gene Symbol
  • HDAC3
  • SMAP45
  • HD3
  • RPD3
  • RPD3-2
Purification MethodProtein A chromatography
UniProt Number
UniProt SummaryFUNCTION: SwissProt: O15379 # Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor.
SIZE: 428 amino acids; 48848 Da
SUBUNIT: Interacts with HDAC7 and HDAC9. Forms a heterologous complex at least with YY1. Interacts with DAXX, HDAC10 and DACH1. Found in a complex with NCOR1 and NCOR2. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with BCOR, MJD2A/JHDM3A, NRIP1 and SRY. Interacts with BTBD14B. Interacts with GLIS2 (By similarity). Interacts with CBFA2T3.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Widely expressed.
PTM: Sumoylated in vitro.
SIMILARITY: SwissProt: O15379 ## Belongs to the histone deacetylase family. Type 1 subfamily.
Molecular Weight49kDa
Product Usage Statements
Quality Assuranceroutinely evaluated by immunoblot on a HeLa RIPA cell lysate
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions2 years at -20°C
Packaging Information
Material Size200 µg
Global Trade Item Number
Catalogue Number GTIN
06-890 04053252325977