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176872 Angiotensin Converting Enzyme-2, His•Tag®, Human, Recombinant, NSO Cells

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ACE Homolog, ACEH, ACE-2

176872
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Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
176872-10UGCN Glass bottle 10 μg
Description
OverviewRecombinant, human ACE-2 ectodomain (amino acids 1-740) fused at the C-terminus to a His•Tag® sequence and expressed in NSO cells. Native ACE-2 is an integral membrane zinc metalloprotease that can be inhibited by EDTA. ACE-2 cleaves angiotensins I and II. Plays an important role in regulating cardiovascular and renal functions. By SDS-PAGE, the apparent molecular mass of the glycosylated protein is ~120 kDa under either reducing or non-reducing condition.
Catalogue Number176872
Brand Family Calbiochem®
SynonymsACE Homolog, ACEH, ACE-2
References
ReferencesTikellis, C., et al. 2003. Hypertension 41, 390.
Tipnis, S.R., et al. 2000. J. Biol. Chem. 275, 33238.
Product Information
Unit of DefinitionOne unit is defined as the amount of enzyme that will cleave 1 nmol MCA-YVADAPK(DNP)-OH per min at 25°C, pH 7.5.
FormLiquid
Quality LevelMQ100
Applications
Biological Information
Purity≥90% by SDS-PAGE
Specific Activity≥0.8 unit/µg protein
Concentration Label Please refer to vial label for lot-specific concentration
Physicochemical Information
ContaminantsEndotoxins: ≤1.0 EU/µg ACE-2
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
176872-10UGCN 04055977222999

Documentation

Angiotensin Converting Enzyme-2, His•Tag®, Human, Recombinant, NSO Cells SDS

Title

Safety Data Sheet (SDS) 

Angiotensin Converting Enzyme-2, His•Tag®, Human, Recombinant, NSO Cells Certificates of Analysis

TitleLot Number
176872

References

Reference overview
Tikellis, C., et al. 2003. Hypertension 41, 390.
Tipnis, S.R., et al. 2000. J. Biol. Chem. 275, 33238.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-April-2008 RFH
SynonymsACE Homolog, ACEH, ACE-2
DescriptionRecombinant, human ACE-2 ectodomain (amino acids 1-740) fused at the C-terminus to a His•Tag® sequence and expressed in NSO cells. ACE-2 cleaves angiotensins I and II as a carboxypeptidase and plays an important role in regulating cardiovascular and renal functions. Native ACE-2 is an integral membrane zinc metalloprotease whose activity is inhibited by EDTA. By SDS-PAGE, the apparent molecular mass of the glycosylated protein is ~120 kDa under either reducing or non-reducing conditions.
FormLiquid
Concentration Label Please refer to vial label for lot-specific concentration
Purity≥90% by SDS-PAGE
ContaminantsEndotoxins: ≤1.0 EU/µg ACE-2
Specific activity≥0.8 unit/µg protein
Unit definitionOne unit is defined as the amount of enzyme that will cleave 1 nmol MCA-YVADAPK(DNP)-OH per min at 25°C, pH 7.5.
Storage Avoid freeze/thaw
≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Toxicity Standard Handling
ReferencesTikellis, C., et al. 2003. Hypertension 41, 390.
Tipnis, S.R., et al. 2000. J. Biol. Chem. 275, 33238.