175580 Sigma-AldrichAngiogenesis Inhibitor - CAS 186611-44-9 - Calbiochem
The Angiogenesis Inhibitor, also referenced under CAS 186611-44-9, controls the biological activity of Angiogenesis. This small molecule/inhibitor is primarily used for Phosphorylation & Dephospho
More>> The Angiogenesis Inhibitor, also referenced under CAS 186611-44-9, controls the biological activity of Angiogenesis. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: (Z,E)-3-(Imidazol-4-ylmethylene)indolin-2-one
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 186611-44-9 | C₁₂H₉N₃O |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 175580-10MGCN | Plastic ampoule | 10 mg |
| Description | |
|---|---|
| Overview | A cell-permeable indolinone compound that displays anti-angiogenesis properties (30% inhibition of control at 10 µM in an in vitro rat aortic ring model ) with a potency that is comparable to that of SU5416 (Cat. No. 676487; 22% inhibition of control at 10 µM). Acts as a moderate ATP-competitive inhibitor of hEGF-R tyrosine kinase activity (54% inhibition at 10 µM). |
| Catalogue Number | 175580 |
| Brand Family | Calbiochem® |
| Synonyms | (Z,E)-3-(Imidazol-4-ylmethylene)indolin-2-one |
| References | |
|---|---|
| References | Braud, E., et al. 2003. J. Enzyme Inhib. Med. Chem. 18, 243. |
| Product Information | |
|---|---|
| CAS number | 186611-44-9 |
| ATP Competitive | Y |
| Form | Yellow solid |
| Hill Formula | C₁₂H₉N₃O |
| Chemical formula | C₁₂H₉N₃O |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | hEGF-R tyrosine kinase activity |
| Primary Target IC<sub>50</sub> | 54% inhibition at 10 µM against hEGF-R tyrosine kinase activity |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 175580-10MGCN | 04055977222920 |