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126855 Alendronate, Sodium Salt - CAS 121268-17-5 - Calbiochem

An amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Alendronate, Sodium, Trihydrate, 4-Amino-1-hydroxybutylidine-1,1-bisphosphonate

Primary Target: Farnesyl diphosphate synthase
126855
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
121268-17-5C₄H₁₂NNaO₇P₂ • 3H₂O

Products

Catalogue NumberPackaging Qty/Pack
126855-100MGCN Plastic ampoule 100 mg
Description
OverviewAn amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction. Causes disruption of the ruffled border and actin cytoskeleton of osteoclasts and induces in vitro apoptosis of osteoclasts and macrophages by inhibiting farnesyl diphosphate synthase (IC50 = 460 nM). Efficiently chelates metal ions and functions as a broad-spectrum MMP inhibitor (IC50 ~ 40 - 70 µM). Also displays antimetastatic, anti-invasive and cell-adhesion-promoting properties (IC50 ~ 1 pM, in vitro invasion of prostate cancer cells).
Catalogue Number126855
Brand Family Calbiochem®
SynonymsAlendronate, Sodium, Trihydrate, 4-Amino-1-hydroxybutylidine-1,1-bisphosphonate
References
ReferencesLehenkari, P.P., et al. 2002. Mol. Pharmacol. 62, 1255.
Virtanen, S.S., et al. 2002. Cancer Res. 62, 2708.
Bergstrom, J.D., et al. 2000. Arch. Biochem. Biophys. 373, 231.
Smith, R., et al. 1971. Lancet 1, 945.
Fleisch, H., et al. 1969. Nature 223, 211.
Product Information
CAS number121268-17-5
ATP CompetitiveN
FormWhite solid
Hill FormulaC₄H₁₂NNaO₇P₂ • 3H₂O
Chemical formulaC₄H₁₂NNaO₇P₂ • 3H₂O
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetFarnesyl diphosphate synthase
Primary Target IC<sub>50</sub>460 nM against farnesyl diphosphate synthase; ~ 40 - 70 µM as as a broad-spectrum MMP inhibitor; ~ 1 pM against in vitro invasion of prostate cancer cells
Purity≥98% by titration
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSSZ6523500
Safety Information
R PhraseR: 22;
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
126855-100MGCN 04055977222142

Documentation

Alendronate, Sodium Salt - CAS 121268-17-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Alendronate, Sodium Salt - CAS 121268-17-5 - Calbiochem Certificates of Analysis

TitleLot Number
126855

References

Reference overview
Lehenkari, P.P., et al. 2002. Mol. Pharmacol. 62, 1255.
Virtanen, S.S., et al. 2002. Cancer Res. 62, 2708.
Bergstrom, J.D., et al. 2000. Arch. Biochem. Biophys. 373, 231.
Smith, R., et al. 1971. Lancet 1, 945.
Fleisch, H., et al. 1969. Nature 223, 211.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-April-2008 RFH
SynonymsAlendronate, Sodium, Trihydrate, 4-Amino-1-hydroxybutylidine-1,1-bisphosphonate
DescriptionAn amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction. Causes disruption of the ruffled border and actin cytoskeleton of osteoclasts. Shown to induce apoptosis of osteoclasts and macrophages. Inhibits farnesyl disphosphate synthase (IC50 = 460 nM with purified enzyme and 1.7 µM with cell extracts). Also shown to inhibit migration, cell adhesion, and invasion of cells (IC50 = 1 pM in prostate cancer cell invasion assays). Efficiently chelates metal ions and functions as a matrix metalloprotease (MMP) inhibitor (IC50 = 40-70 µM).
FormWhite solid
CAS number121268-17-5
RTECSSZ6523500
Chemical formulaC₄H₁₂NNaO₇P₂ • 3H₂O
Structure formulaStructure formula
Purity≥98% by titration
SolubilityH₂O (10 mg/ml)
Storage +2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Harmful
Merck USA index14, 229
ReferencesLehenkari, P.P., et al. 2002. Mol. Pharmacol. 62, 1255.
Virtanen, S.S., et al. 2002. Cancer Res. 62, 2708.
Bergstrom, J.D., et al. 2000. Arch. Biochem. Biophys. 373, 231.
Smith, R., et al. 1971. Lancet 1, 945.
Fleisch, H., et al. 1969. Nature 223, 211.