124014 Sigma-AldrichAkt Inhibitor VII, TAT-Akt-in - Calbiochem
The Akt Inhibitor VII, TAT-Akt-in controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The Akt Inhibitor VII, TAT-Akt-in controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: H-YGRKKRRQRRR-AVTDHPDRLWAWEKF-OH, TAT-TCL1₁₀₋₂₄
Recommended Products
Overview
| Replacement Information |
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Key Spec Table
| Empirical Formula |
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| C₁₅₂H₂₃₉N₅₅O₃₆ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 124014-2MGCN | Plastic ampoule | 2 mg |
| Description | |
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| Overview | A cell-permeable and reversible version of the Akt Inhibitor VI, Akt-in (Cat. No. 124013) fused with the protein transduction domain TAT that displays antitumor properties. Inhibits the phosphorylation of Akt selectively in HEK 293 and QRsP-11 fibrosarcoma cells stimulated with PDGF (complete inhibition at ~50 µM) with minimal inhibition towards PKA, PKC, PDK1, p42/44 MAPK, or p38 MAPK. Shown to prevent the proliferation of T4 cells, and tumor growth in syngeneic C57BL/6 mice. |
| Catalogue Number | 124014 |
| Brand Family | Calbiochem® |
| Synonyms | H-YGRKKRRQRRR-AVTDHPDRLWAWEKF-OH, TAT-TCL1₁₀₋₂₄ |
| References | |
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| References | Hiromura, M., et al. 2004. J. Biol. Chem. 279, 53407. |
| Product Information | |
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| ATP Competitive | N |
| Form | White solid |
| Formulation | Supplied as an trifluoroacetate salt. |
| Hill Formula | C₁₅₂H₂₃₉N₅₅O₃₆ |
| Chemical formula | C₁₅₂H₂₃₉N₅₅O₃₆ |
| Hygroscopic | Hygroscopic |
| Reversible | Y |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | Akt |
| Primary Target IC<sub>50</sub> | 50 µM against Akt |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Peptide Sequence | H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Ala-Val-Thr-Asp-His-Pro-Asp-Arg-Leu-Trp-Ala-Trp-Glu-Lys-Phe-OH |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 124014-2MGCN | 04055977205664 |
Documentation
Akt Inhibitor VII, TAT-Akt-in - Calbiochem SDS
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Akt Inhibitor VII, TAT-Akt-in - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 124014 |
References
| Reference overview |
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| Hiromura, M., et al. 2004. J. Biol. Chem. 279, 53407. |
Brochure
| Title |
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| Akt |
| Biologics 31.1 |