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182690 AhR Agonist V, VAF347 - CAS 574759-62-9 - Calbiochem

The AhR Agonist V, VAF347 controls the biological activity of AhR. This small molecule/inhibitor is primarily used for Biochemicals applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (4-(3-Chloro-phenyl)-pyrimidin-2-yl)-(4-trifluoromethyl-phenyl)-amine

182690
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Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
182690-10MGCN Glass bottle 10 mg
Description
OverviewA cell-permeable pyrimidinylphenylamine compound that directly and reversibly targets aryl hydrocarbon receptor (AhR) with high-affinity, and induces AhR signaling. Reported to act as an immunomodulator with anti-inflammatory properties. Potently suppresses IgE secretion in B-cells with an IC50 of ~2 nM, and inhibits dendritic cells-mediated T-cell proliferation and cytokine production. Further, decreases lung eosinophilia in B-cell-deficient mice, and allergic inflammation. Downregulates PU.1 transcription factor, and impairs human monocytes and Langerhans dendritic cells differentiation.
Catalogue Number182690
Brand Family Calbiochem®
Synonyms(4-(3-Chloro-phenyl)-pyrimidin-2-yl)-(4-trifluoromethyl-phenyl)-amine
References
ReferencesPlatzer, B., et al. 2009. J. Immunol. 183, 66.
Hauben, E., et al. 2008. Blood 118, 1214.
Lawrence, B.P., et al. 2008. Blood 112, 1158.
Ettmayer, P., et al. 2006. Am. J. Respir. Crit. Care Med. 173, 599.
Product Information
CAS number574759-62-9
FormWhite solid
Hill FormulaC₁₇H₁₁ClF₃N₃
Chemical formulaC₁₇H₁₁ClF₃N₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
182690-10MGCN 04055977204445

Documentation

AhR Agonist V, VAF347 - CAS 574759-62-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

AhR Agonist V, VAF347 - CAS 574759-62-9 - Calbiochem Certificates of Analysis

TitleLot Number
182690

References

Reference overview
Platzer, B., et al. 2009. J. Immunol. 183, 66.
Hauben, E., et al. 2008. Blood 118, 1214.
Lawrence, B.P., et al. 2008. Blood 112, 1158.
Ettmayer, P., et al. 2006. Am. J. Respir. Crit. Care Med. 173, 599.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision24-August-2012 JSW
Synonyms(4-(3-Chloro-phenyl)-pyrimidin-2-yl)-(4-trifluoromethyl-phenyl)-amine
DescriptionA cell-permeable pyrimidinylphenylamine compound that directly and reversibly targets aryl hydrocarbon receptor (AhR) with high-affinity, and induces AhR signaling. Reported to act as an immunomodulator with anti-inflammatory properties. Potently suppresses IgE secretion in B-cells with an IC50 of ~2 nM, and inhibits dendritic cells-mediated T-cell proliferation and cytokine production. Further, decreases lung eosinophilia in B-cell-deficient mice, and allergic inflammation. Downregulates PU.1 transcription factor, and impairs human monocytes and Langerhans dendritic cells differentiation.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number574759-62-9
Chemical formulaC₁₇H₁₁ClF₃N₃
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesPlatzer, B., et al. 2009. J. Immunol. 183, 66.
Hauben, E., et al. 2008. Blood 118, 1214.
Lawrence, B.P., et al. 2008. Blood 112, 1158.
Ettmayer, P., et al. 2006. Am. J. Respir. Crit. Care Med. 173, 599.