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123850 AKR1C1 Inhibitor, 5-PBSA - CAS 4906-68-7 - Calbiochem

123850
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Overview

Key Spec Table

CAS #Empirical Formula
4906-68-7C₁₃H₉BrO₃

Products

Catalogue NumberPackaging Qty/Pack
123850-25MGCN Glass bottle 25 mg
Description
OverviewA cell-permeable salicylic acid compound that acts as a highly potent, active-site directed and substrate competitive AKR1C1 inhibitor (Ki = 4 nM) with moderate to excellent selectivity over AKR1C2, AKR1C3 and AKR1C4 (Ki = 0.087, 4.2 and 18.2 µM, respectively). Shown to inhibit the metabolism of progesterone by AKR1C1 (IC50 = 460 nM in AKR1C1 overexpressing BAECs).
Catalogue Number123850
Brand Family Calbiochem®
SynonymsAldo-Keto Reductase family 1 member C1 Inhibitor, 5-PBSA, 3-Bromo-5-phenylsalicylic acid, 20α-Hydroxysteroid Dehydrogenase Inhibitor, 5-PBSA
References
ReferencesEl-Kabbani, O., et al. 2011. J. Steroid Biochem. Mol. Biol. 125, 105.
El-Kabbani, O., et al. 2009. J. Med. Chem. 52, 3259.
Product Information
CAS number4906-68-7
FormWhite solid
Hill FormulaC₁₃H₉BrO₃
Chemical formulaC₁₃H₉BrO₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥94% by HPLC
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
123850-25MGCN 04055977206296