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220467 2-Chloro-2ʹ-deoxyadenosine - CAS 4291-63-8 - Calbiochem

A deoxyadenosine analog that displays strong antileukemic and immunosuppressive activity.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2CdA, Cladribine

Primary Target: Antileukemic and immunosuppressive activity
220467
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
4291-63-8C₁₀H₁₂ClN₅O₃

Products

Catalogue NumberPackaging Qty/Pack
220467-10MGCN Plastic ampoule 10 mg
Description
OverviewA deoxyadenosine analog that displays strong antileukemic and immunosuppressive activity. Also induces apoptosis in chronic lymphocytic leukemia (CLL) cells.
Catalogue Number220467
Brand Family Calbiochem®
Synonyms2CdA, Cladribine
References
ReferencesBellosillo, B., et al. 1997. Blood 89, 3378; Bryson, H.M., and Sorkin, E.M. 1993. Drugs 46, 872.
Robertson, L.E., et al. 1993. Blood 81, 143.
Carson, D.A., et al. 1988. Adv. Enzyme Regul. 27, 395.
Carson, D.A., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 2232.
Product Information
CAS number4291-63-8
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₀H₁₂ClN₅O₃
Chemical formulaC₁₀H₁₂ClN₅O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetAntileukemic and immunosuppressive activity
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSAU7357560
Safety Information
R PhraseR: 20/21/22-36/37/38-40

Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
Limited evidence of a carcinogenic effect.
S PhraseS: 22-24/25-26-36/37/39-45

Do not breathe dust.
Avoid contact with skin and eyes.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
220467-10MGCN 04055977201116

Documentation

2-Chloro-2ʹ-deoxyadenosine - CAS 4291-63-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

2-Chloro-2ʹ-deoxyadenosine - CAS 4291-63-8 - Calbiochem Certificates of Analysis

TitleLot Number
220467

References

Reference overview
Bellosillo, B., et al. 1997. Blood 89, 3378; Bryson, H.M., and Sorkin, E.M. 1993. Drugs 46, 872.
Robertson, L.E., et al. 1993. Blood 81, 143.
Carson, D.A., et al. 1988. Adv. Enzyme Regul. 27, 395.
Carson, D.A., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 2232.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-April-2008 RFH
Synonyms2CdA, Cladribine
DescriptionA deoxyadenosine analog that displays strong antileukemic and immunosuppressive activity. Also induces apoptosis in chronic lymphocytic leukemia (CLL) cells.
FormWhite solid
CAS number4291-63-8
RTECSAU7357560
Chemical formulaC₁₀H₁₂ClN₅O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful & Carcinogenic / Teratogenic
Merck USA index14, 2337
ReferencesBellosillo, B., et al. 1997. Blood 89, 3378; Bryson, H.M., and Sorkin, E.M. 1993. Drugs 46, 872.
Robertson, L.E., et al. 1993. Blood 81, 143.
Carson, D.A., et al. 1988. Adv. Enzyme Regul. 27, 395.
Carson, D.A., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 2232.