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100069 17-DMAG - CAS 467214-21-7 - Calbiochem

17-DMAG, CAS 467214-21-7, is a more potent antitumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90α with high affinity (GI50 = 51 nM).

17-DMAG - CAS 467214-21-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NSC 707545, 17-Desmethoxy-17-N,N-dimethylaminoethylamino-geldanamycin, HCl, 17-N,N-Dimethylaminoethylamino-17-demethoxy-geldanamycin, HCl, 17DMAG

Primary Target: 17-DMAG
100069
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Overview

Key Spec Table

CAS #Empirical Formula
467214-21-7C₃₂H₄₈N₄O₈ • HCl

Products

Catalogue NumberPackaging Qty/Pack
100069-500UGCN Plastic ampoule 500 μg
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Description
OverviewA potent antitumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90α with high affinity (GI50 = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen), and displays excellent bioavailability and aqueous solubility.
Catalogue Number100069
Brand Family Calbiochem®
SynonymsNSC 707545, 17-Desmethoxy-17-N,N-dimethylaminoethylamino-geldanamycin, HCl, 17-N,N-Dimethylaminoethylamino-17-demethoxy-geldanamycin, HCl, 17DMAG
References
ReferencesTian, Z.Q., et al. 2004. Bioorg. Med. Chem. 12, 5317.
Jez, J.M., et al. 2003. Chem. Biol. 10, 361.
Egorin, M.J., et al. 2002. Cancer Chemother. Pharmacol. 49, 7.
Product Information
CAS number467214-21-7
ATP CompetitiveN
FormPurple solid
Hill FormulaC₃₂H₄₈N₄O₈ • HCl
Chemical formulaC₃₂H₄₈N₄O₈ • HCl
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Application17-DMAG, CAS 467214-21-7, is a more potent antitumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90α with high affinity (GI50 = 51 nM).
Biological Information
Primary Target17-DMAG
Primary Target IC<sub>50</sub>GI50 = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
100069-500UGCN 04055977226188