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565773 γ-Secretase Inhibitor XII - Calbiochem

γ-Secretase Inhibitor XII, is a cell-permeable, reversible inhibitor of γ-secretase activity in vitro (Aβ40 IC50 = 7.9 µM; Aβ42 IC50 = 7.6 µM) and in APP695 expressing CHO 2b-7 cells.

γ-Secretase Inhibitor XII - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-IL-CHO

Primary Target: Aβ40 in vitro
565773
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₀H₃₀N₂O₄

Products

Catalogue NumberPackaging Qty/Pack
565773-5MGCN Plastic ampoule 5 mg
Description
OverviewA cell-permeable, reversible dipeptide aldehyde that reduces Aβ production by blocking γ-secretase activity in vitro (Aβ40 IC50 = 7.9 µM; Aβ42 IC50 = 7.6 µM) and in cultured CHO 2b-7 cells that stably overexpress APP695 (Aβ40 IC50 = 11.5 µM; Aβ42 IC50 = 8.3 µM). Also blocks the generation of CTFγ (γ-secretase-generated carboxyl-terminal fragment). Does not affect the formation of amyloid-β-precursor protein (APP).
Catalogue Number565773
Brand Family Calbiochem®
SynonymsZ-IL-CHO
References
ReferencesWeijzen, S., et al. 2002. Nat. Med. 8, 979.
McLendon, C., et al. 2000. FASEB J. 14, 2383.
Product Information
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₀H₃₀N₂O₄
Chemical formulaC₂₀H₃₀N₂O₄
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Applicationγ-Secretase Inhibitor XII, is a cell-permeable, reversible inhibitor of γ-secretase activity in vitro (Aβ40 IC50 = 7.9 µM; Aβ42 IC50 = 7.6 µM) and in APP695 expressing CHO 2b-7 cells.
Biological Information
Primary TargetAβ40 in vitro
Primary Target IC<sub>50</sub>7.9 µM for Aβ40; 7.6 µM for Aβ42 in vitro
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceZ-Ile-Leu-CHO
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
565773-5MGCN 04055977267860

Documentation

γ-Secretase Inhibitor XII - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

γ-Secretase Inhibitor XII - Calbiochem Certificates of Analysis

TitleLot Number
565773

References

Reference overview
Weijzen, S., et al. 2002. Nat. Med. 8, 979.
McLendon, C., et al. 2000. FASEB J. 14, 2383.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-September-2008 RFH
SynonymsZ-IL-CHO
DescriptionA cell-permeable, reversible dipeptide aldehyde that reduces amyloid-β protein (Aβ) production by blocking γ-secretase activity in vitro (Aβ40 IC50 = 7.9 µM; Aβ42 IC50 = 7.6 µM) and in cultured cells that stably over-express APP695 (Aβ40 IC50 = 11.5 µM; Aβ42 IC50 = 8.3 µM). Also shown to block the generation of γCTF (γ-secretase-generated carboxy-terminal fragment).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₀H₃₀N₂O₄
Peptide SequenceZ-Ile-Leu-CHO
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesWeijzen, S., et al. 2002. Nat. Med. 8, 979.
McLendon, C., et al. 2000. FASEB J. 14, 2383.