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565761 γ-Secretase Inhibitor IV - Calbiochem

565761
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Overview

Key Spec Table

Empirical Formula
C₂₅H₂₆N₂O₃

Products

Catalogue NumberPackaging Qty/Pack
565761-1MGCN Plastic ampoule 1 mg
Description
OverviewA cell-permeable, reversible inhibitor of γ-secretase. Equipotently inhibits the release of Aβx-40 (ED50 = 2.6 µM) and Aβx-42 (ED50 = 2.7 µM) in HEK293 cells stably transfected with the Amyloid Precursor Protein Swedish mutants.
Catalogue Number565761
Brand Family Calbiochem®
Synonyms2-Naphthoyl-VF-CHO, N-(2-Naphthoyl)-Val-phenylalaninal
References
ReferencesGreen, K.N., et al. 2002. J. Physiol. 541.3, 1013.
Sinha, S. and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
Product Information
ATP CompetitiveN
FormWhite lyophilized solid
Hill FormulaC₂₅H₂₆N₂O₃
Chemical formulaC₂₅H₂₆N₂O₃
ReversibleY
Quality LevelMQ100
Biological Information
Primary Targetx-40
Primary Target IC<sub>50</sub>ED50 = 2.6 µM for Aβx-40
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide Sequence2-Naphthoyl-Val-Phe-CHO
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
565761-1MGCN 04055977267716