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203980 α-Bungarotoxin, Bungarus multicinctus - CAS 11032-79-4 - Calbiochem

Blocks neuromuscular transmission by irreversible binding to motor end-plate acetylcholine receptor (Kd = 1 pM to 1 nM) but does not depress acetylcholine release from motor nerve endings.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
203980
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
11032-79-4C₃₃₈H₅₂₉N₉₇O₁₀₅S₁₁

Products

Catalogue NumberPackaging Qty/Pack
203980-1MGCN Plastic ampoule 1 mg
Description
OverviewBlocks neuromuscular transmission by irreversible binding to motor end-plate acetylcholine receptor (Kd = 1 pM to 1 nM) but does not depress acetylcholine release from motor nerve endings. Blocks nicotine-induced increase of intracellular Ca2+ in PC12 cells (IC50 = 310 nM), and prevents opening of nicotinic receptor-associated ion channels. Reconstitution experiments in Xenopus oocytes have shown the effects of α-bungarotoxin on neuronal nAChR to be highly specific for the α7-subtype (IC50 = 1.6 nM), but not for the α3β4-subtype (IC50 >3 µM).
Catalogue Number203980
Brand Family Calbiochem®
References
ReferencesLopez, M.G., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14184.
Zhang, Z.W., et al. 1994. Neuron 12, 167.
Bambrick, L.L., and Gordon, T. 1992. J. Physiol. 449, 479.
Lin, S.R., and Chang, C.C. 1992. Biochim. Biophys. Acta 1159, 255.
Motomura, M., et al. 1992. Neurosci. Lett. 143, 139.
Sorenson, E.M., and Chiappinelli, V.A. 1992. J. Comp. Neurol. 323, 1.
Ruan, K.H., et al. 1990. 87, 6156.
Product Information
CAS number11032-79-4
ATP CompetitiveN
FormLyophilized solid
Hill FormulaC₃₃₈H₅₂₉N₉₇O₁₀₅S₁₁
Chemical formulaC₃₃₈H₅₂₉N₉₇O₁₀₅S₁₁
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetMotor end-plate acetylcholine receptor
Primary Target IC<sub>50</sub>Kd = 1 pM to 1 nM for motor end-plate acetylcholine receptor
Physicochemical Information
Cell permeableN
ContaminantsNone detectable by IEF. Supplied as an acetate salt
Peptide SequenceH-Ile-Val-Cys³-His-Thr-Thr-Ala-Thr-Ser-Pro-Ile-Ser-Ala-Val-Thr-Cys¹⁶-Pro-Pro-Gly-Glu-Asn-Leu-Cys²³-Tyr-Arg-Lys-Met-Trp-Cys²⁹-Asp-Ala-Phe-Cys³³-Ser-Ser-Arg-Gly-Lys-Val-Val-Glu-Leu-Gly-Cys⁴⁴-Ala-Ala-Thr-Cys⁴⁸-Pro-Ser-Lys-Lys-Pro-Tyr-Glu-Glu-Val-Thr-Cys⁵⁹-Cys⁶⁰-Ser-Thr-Asp-Lys-Cys⁶⁵-Asn-Pro-His-Pro-Lys-Gln-Arg-Pro-Gly-OH (disulfide bonds: 3 → 23; 16 → 44; 29 → 33; 48 → 59; 60 → 65)
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSEI6201400
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
203980-1MGCN 04055977219944

Documentation

α-Bungarotoxin, Bungarus multicinctus - CAS 11032-79-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

α-Bungarotoxin, Bungarus multicinctus - CAS 11032-79-4 - Calbiochem Certificates of Analysis

TitleLot Number
203980

References

Reference overview
Lopez, M.G., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14184.
Zhang, Z.W., et al. 1994. Neuron 12, 167.
Bambrick, L.L., and Gordon, T. 1992. J. Physiol. 449, 479.
Lin, S.R., and Chang, C.C. 1992. Biochim. Biophys. Acta 1159, 255.
Motomura, M., et al. 1992. Neurosci. Lett. 143, 139.
Sorenson, E.M., and Chiappinelli, V.A. 1992. J. Comp. Neurol. 323, 1.
Ruan, K.H., et al. 1990. 87, 6156.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-April-2008 RFH
DescriptionA polypeptide composed of 74 amino acids containing 5 disulfide bridges. Blocks neuromuscular transmission by irreversible binding to the motor end-plate acetylcholine receptor (Kd = 1 nM to 1 pM) but does not depress acetylcholine release from motor nerve endings. Blocks nicotine-induced augmentation in intracellular Ca2+ in PC12 cells (IC50 = 310 nM). Prevents opening of nicotinic receptor-associated ion channels. Reconstitution experiments in Xenopus oocytes have shown the effects of α-Bungarotoxin on neuronal nAChR to be highly specific for the α7-subtype (IC50 = 1.6 nM), but not for the α3β4-subtype (IC50 > 3 µM).
FormLyophilized solid
CAS number11032-79-4
RTECSEI6201400
Chemical formulaC₃₃₈H₅₂₉N₉₇O₁₀₅S₁₁
Peptide SequenceH-Ile-Val-Cys³-His-Thr-Thr-Ala-Thr-Ser-Pro-Ile-Ser-Ala-Val-Thr-Cys¹⁶-Pro-Pro-Gly-Glu-Asn-Leu-Cys²³-Tyr-Arg-Lys-Met-Trp-Cys²⁹-Asp-Ala-Phe-Cys³³-Ser-Ser-Arg-Gly-Lys-Val-Val-Glu-Leu-Gly-Cys⁴⁴-Ala-Ala-Thr-Cys⁴⁸-Pro-Ser-Lys-Lys-Pro-Tyr-Glu-Glu-Val-Thr-Cys⁵⁹-Cys⁶⁰-Ser-Thr-Asp-Lys-Cys⁶⁵-Asn-Pro-His-Pro-Lys-Gln-Arg-Pro-Gly-OH (disulfide bonds: 3 → 23; 16 → 44; 29 → 33; 48 → 59; 60 → 65)
ContaminantsNone detectable by IEF. Supplied as an acetate salt
SolubilityH₂O or PBS
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Harmful
Merck USA index14, 1488
ReferencesLopez, M.G., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14184.
Zhang, Z.W., et al. 1994. Neuron 12, 167.
Bambrick, L.L., and Gordon, T. 1992. J. Physiol. 449, 479.
Lin, S.R., and Chang, C.C. 1992. Biochim. Biophys. Acta 1159, 255.
Motomura, M., et al. 1992. Neurosci. Lett. 143, 139.
Sorenson, E.M., and Chiappinelli, V.A. 1992. J. Comp. Neurol. 323, 1.
Ruan, K.H., et al. 1990. 87, 6156.